2023

Generating parallel representations of position and identity in the olfactory system

Ricca's factors as mobile proteinaceous effectors of electrical signaling

Sparse and stereotyped encoding implicates a core glomerulus for ant alarm behavior

2022

A male-derived nonribosomal peptide pheromone controls female schistosome development

Scent of a human: The mosquito olfactory system defies dogma to ensure attraction to humans

2021

Evolutionary assembly of cooperating cell types in an animal chemical defense system

2020

Genomes of the Banyan Tree and Pollinator Wasp Provide Insights into Fig-Wasp Coevolution

2019

Limbic Neurons Shape Sex Recognition and Social Behavior in Sexually Naive Males

Engineering a Model Cell for Rational Tuning of GPCR Signaling

A Jasmonate Signaling Network Activates Root Stem Cells and Promotes Regeneration

2018

Multisensory Logic of Infant-Directed Aggression by Males

Real-Time Genetic Compensation Defines the Dynamic Demands of Feedback Control

2017

An Engineered orco Mutation Produces Aberrant Social Behavior and Defective Neural Development in Ants

orco Mutagenesis Causes Loss of Antennal Lobe Glomeruli and Impaired Social Behavior in Ants

2016

A Family of non-GPCR Chemosensors Defines an Alternative Logic for Mammalian Olfaction

Ecology and Evolution of Communication in Social Insects

2015

Cyclic Regulation of Sensory Perception by a Female Hormone Alters Behavior

Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition

A Molecular Code for Identity in the Vomeronasal System

2014

Murine pheromone proteins constitute a context-dependent combinatorial code governing multiple social behaviors

"Sex-specific aging in flies, worms, and missing great-granddads"

2013

A bidirectional circuit switch reroutes pheromone signals in male and female brains

A super-assembly of Whi3 encodes memory of deceptive encounters by single cells during yeast courtship

2012

Contact chemoreceptors mediate male-male repulsion and male-female attraction during Drosophila courtship

CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression

2010

The chemical MUPpeteer

The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs

2008

Activation of pheromone-sensitive neurons is mediated by conformational activation of pheromone-binding protein

LUSH shapes up for a starring role in olfaction

2007

Comprehensive maps of Drosophila higher olfactory centers: spatially segregated fruit and pheromone representation

A map of olfactory representation in the Drosophila mushroom body

A mechanism for cell-cycle regulation of MAP kinase signaling in a yeast differentiation pathway

Tuning bulk electrostatics to regulate protein function

2006

Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes

Heterotrimeric G protein signaling: Getting inside the cell

Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome

2005

Feedback loops link odor and pheromone signaling with reproduction

A nose by any other name (should smell as sweetly)

fruitless splicing specifies male courtship behavior in Drosophila

Neural circuitry that governs Drosophila male courtship behavior

Olfactory inputs to hypothalamic neurons controlling reproduction and fertility

2004

Fus3-regulated Tec1 degradation through SCFCdc4 determines MAPK signaling specificity during mating in yeast

Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast

2003

Functional expression of murine V2R pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules

2002

"Pheromones, vomeronasal function, and gender-specific behavior"

2000

The molecular architecture of odor and pheromone sensing in mammals

1999

A map of pheromone receptor activation in the mammalian brain

Nuclear shuttling of yeast scaffold Ste5 is required for its recruitment to the plasma membrane and activation of the mating MAPK cascade

BiP acts as a molecular ratchet during posttranslational transport of prepro-alpha factor across the ER membrane

Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity

Variable patterns of axonal projections of sensory neurons in the mouse vomeronasal system

1998

Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway

1997

A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution

Binding of secretory precursor polypeptides to a translocon subcomplex is regulated by BiP

MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation

A multigene family encoding a diverse array of putative pheromone receptors in mammals

Impaired maternal behavior in mice lacking norepinephrine and epinephrine

tea1 and the microtubular cytoskeleton are important for generating global spatial order within the fission yeast cell

1996

Mother and daughter are doing fine: asymmetric cell division in yeast

A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S. cerevisiae

A 700 bp cis-acting region controls mating-type dependent recombination along the entire left arm of yeast chromosome III

Origins of cell polarity

Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis

1995

A novel family of genes encoding putative pheromone receptors in mammals

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast

MAP kinase pathways in yeast: for mating and more

Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans

1994

Biochemical and genetic characterization of a competence pheromone from B. subtilis

1993

Bacterial sex pheromone-induced plasmid transfer

How and why bacteria talk to each other

FAR1 links the signal transduction pathway to the cell cycle machinery in yeast

Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres

1992

The a mating type locus of U. maydis specifies cell signaling components

Endocytosis in yeast: evidence for the involvement of a small GTP-binding protein (Ypt7p)

A position effect on the time of replication origin activation in yeast

Yeast pheromone receptor endocytosis and hyperphosphorylation are independent of G protein-mediated signal transduction

1991

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae

Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions

Pheromone-induced phosphorylation of a G protein beta subunit in S. cerevisiae is associated with an adaptive response to mating pheromone

A potential positive feedback loop controlling CLN1 and CLN2 gene expression at the start of the yeast cell cycle

SGV1 encodes a CDC28/cdc2-related kinase required for a G alpha subunit-mediated adaptive response to pheromone in S. cerevisiae

S. cerevisiae alpha pheromone receptors activate a novel signal transduction pathway for mating partner discrimination

1990

"Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2"

FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation

Courtship in S. cerevisiae: both cell types choose mating partners by responding to the strongest pheromone signal

The ERD2 gene determines the specificity of the luminal ER protein retention system

FAR-reaching discoveries about the regulation of START

DNA binding-induced conformational change of the yeast transcriptional activator PRTF

"G1-specific cyclins of S. cerevisiae: cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase"

1989

Constitutive mutants in the yeast pheromone response: ordered function of the gene products

Epigenetic inheritance of transcriptional states in S. cerevisiae

A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae

RAP-1 factor is necessary for DNA loop formation in vitro at the silent mating type locus HML

The STE4 and STE18 genes of yeast encode potential beta and gamma subunits of the mating factor receptor-coupled G protein

1988

a1 protein alters the DNA binding specificity of alpha 2 repressor

A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain

The C-terminus of the S. cerevisiae alpha-pheromone receptor mediates an adaptive response to pheromone

The carboxy-terminal segment of the yeast alpha-factor receptor is a regulatory domain

Reconstitution of SEC gene product-dependent intercompartmental protein transport

1987

"MAT alpha 1 protein, a yeast transcription activator, binds synergistically with a second protein to a set of cell-type-specific genes"

Conservation of a receptor/signal transduction system

"Dual regulation of the yeast CDC28-p40 protein kinase complex: cell cycle, pheromone, and nutrient limitation effects"

"GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction"

The yeast SCG1 gene: a G alpha-like protein implicated in the a- and alpha-factor response pathway

Yeast KEX1 gene encodes a putative protease with a carboxypeptidase B-like function involved in killer toxin and alpha-factor precursor processing

A yeast operator overlaps an upstream activation site

1986

In vitro protein translocation across the yeast endoplasmic reticulum: ATP-dependent posttranslational translocation of the prepro-alpha-factor

Down regulation of the alpha-factor pheromone receptor in S. cerevisiae

"Yeast peptide pheromones, a-factor and alpha-factor, activate a common response mechanism in their target cells"

Two yeast mutants defective in endocytosis are defective in pheromone response

"RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor"

Secretion in yeast: reconstitution of the translocation and glycosylation of alpha-factor and invertase in a homologous cell-free system

1985

DNA topoisomerase II is required at the time of mitosis in yeast

The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways

The yeast STE12 product is required for expression of two sets of cell-type specific genes

1984

Glycosylation and processing of prepro-alpha-factor through the yeast secretory pathway

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor

Transcription and regulatory signals at the mating type locus in yeast

1983

Binding of alpha-factor pheromone to yeast a cells: chemical and genetic evidence for an alpha-factor receptor

Control of yeast cell type by the mating type locus: positive regulation of the alpha-specific STE3 gene by the MAT alpha 1 product

Yeast alpha factor is processed from a larger precursor polypeptide: the essential role of a membrane-bound dipeptidyl aminopeptidase

1982

An essential role for cyclic AMP in growth control: the case for yeast

Structure of a yeast pheromone gene (MF alpha): a putative alpha-factor precursor contains four tandem copies of mature alpha-factor

1981

Cell-cycle regulation of yeast histone mRNA

1979

Asymmetry and directionality in production of new cell types during clonal growth: the switching pattern of homothallic yeast

Recovery of S. cerevisiae a cells from G1 arrest by alpha factor pheromone requires endopeptidase action

Replication of each copy of the yeast 2 micron DNA plasmid occurs during the S phase