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Molecules

Title:		Comprehensive Two-Dimensional Gas Chromatography-Mass Spectrometry Analysis of Exhaled Breath Compounds after Whole Grain Diets
Author(s):		Raninen K; Nenonen R; Jarvela-Reijonen E; Poutanen K; Mykkanen H; Raatikainen O;
Address:		"Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland. SIB Labs, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland. VTT Technical Research Centre of Finland, P.O. Box 1000, FI-02044 VTT Espoo, Finland"
Journal Title:		Molecules
Year:		2021
Volume:		20210502
Issue:		9
Page Number:		-
DOI:		10.3390/molecules26092667
ISSN/ISBN:		1420-3049 (Electronic) 1420-3049 (Linking)
Abstract:		"Exhaled breath is a potential noninvasive matrix to give new information about metabolic effects of diets. In this pilot study, non-targeted analysis of exhaled breath volatile organic compounds (VOCs) was made by comprehensive two-dimensional gas chromatography-mass spectrometry (GCxGC-MS) to explore compounds relating to whole grain (WG) diets. Nine healthy subjects participated in the dietary intervention with parallel crossover design, consisting of two high-fiber diets containing whole grain rye bread (WGR) or whole grain wheat bread (WGW) and 1-week control diets with refined wheat bread (WW) before both diet periods. Large interindividual differences were detected in the VOC composition. About 260 VOCs were detected from exhaled breath samples, in which 40 of the compounds were present in more than half of the samples. Various derivatives of benzoic acid and phenolic compounds, as well as some furanones existed in exhaled breath samples only after the WG diets, making them interesting compounds to study further"
Keywords:		Adult Benzoic Acid/chemistry Bread Breath Tests/*methods Cross-Over Studies *Diet *Dietary Fiber Female Finland Gas Chromatography-Mass Spectrometry/*methods Healthy Volunteers Humans Male Middle Aged Phenol/chemistry Volatile Organic Compounds/*analysis;
Notes:		"MedlineRaninen, Kaisa Nenonen, Ringa Jarvela-Reijonen, Elina Poutanen, Kaisa Mykkanen, Hannu Raatikainen, Olavi eng Randomized Controlled Trial Switzerland 2021/06/03 Molecules. 2021 May 2; 26(9):2667. doi: 10.3390/molecules26092667"