« Previous AbstractComprehensive Two-Dimensional Gas Chromatography-Mass Spectrometry Analysis of Exhaled Breath Compounds after Whole Grain Diets    Next Abstract"Improvement in shelf life of minimally processed cilantro leaves through integration of kinetin pretreatment and packaging interventions: Studies on microbial population dynamics, biochemical characteristics and flavour retention" »

Nutr Res

Title:		Fiber content of diet affects exhaled breath volatiles in fasting and postprandial state in a pilot crossover study
Author(s):		Raninen KJ; Lappi JE; Mukkala ML; Tuomainen TP; Mykkanen HM; Poutanen KS; Raatikainen OJ;
Address:		"Institute of Public Health and Clinical Nutrition, University of Eastern Finland, PO Box 1627, 70211, Kuopio, Finland. Electronic address: kaisa.raninen@uef.fi. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, PO Box 1627, 70211, Kuopio, Finland. Electronic address: jenni.lappi@pakkasmarja.fi. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, PO Box 1627, 70211, Kuopio, Finland. Electronic address: maria.mukkala@gmail.com. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, PO Box 1627, 70211, Kuopio, Finland. Electronic address: tomi-pekka.tuomainen@uef.fi. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, PO Box 1627, 70211, Kuopio, Finland. Electronic address: hannu.mykkanen@uef.fi. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, PO Box 1627, 70211, Kuopio, Finland. Electronic address: kaisa.poutanen@vtt.fi. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, PO Box 1627, 70211, Kuopio, Finland. Electronic address: olavi.raatikainen@uef.fi"
Journal Title:		Nutr Res
Year:		2016
Volume:		20160223
Issue:		6
Page Number:		612 - 619
DOI:		10.1016/j.nutres.2016.02.008
ISSN/ISBN:		1879-0739 (Electronic) 0271-5317 (Linking)
Abstract:		"Our pilot study examined the potential of exhaled breath analysis in studying the metabolic effects of dietary fiber (DF). We hypothesized that a high-fiber diet (HFD) containing whole grain rye changes volatile organic compound (VOC) levels in exhaled breath and that consuming a single meal affects these levels. Seven healthy men followed a week-long low-fiber diet (17 g/d) and HFD (44 g/d) in a randomized crossover design. A test meal containing 50 g of the available carbohydrates from wheat bread was served as breakfast after each week. Alveolar exhaled breath samples were analyzed at fasting state and 30, 60, and 120 minutes after this meal parallel to plasma glucose, insulin, and serum lipids. We used solid-phase microextraction and gas chromatography-mass spectrometry for detecting changes in 15 VOCs. These VOCs were acetone, ethanol, 1-propanol, 2-propanol, 1-butanol, acetic acid, propionic acid, butyric acid, valeric acid, isovaleric acid, 2-methylbutyric acid, hexanoic acid, acetoin, diacetyl, and phenol. Exhaled breath 2-methylbutyric acid in the fasting state and 1-propanol at 120 minutes decreased (P = .091 for both) after an HFD. Ingestion of the test meal increased ethanol, 1-propanol, acetoin, propionic acid, and butyric acid levels while reducing acetone, 1-butanol, diacetyl, and phenol levels. Both DF diet content and having a single meal affected breathVOCs. Exploring exhaled breath further could help to develop tools for monitoring the metabolic effects of DF"
Keywords:		Adult Blood Glucose/metabolism Breath Tests Cholesterol/blood Cross-Over Studies *Diet Dietary Carbohydrates/administration & dosage Dietary Fiber/*administration & dosage Energy Metabolism Exercise *Fasting Gas Chromatography-Mass Spectrometry Humans Ins;
Notes:		"MedlineRaninen, Kaisa J Lappi, Jenni E Mukkala, Maria L Tuomainen, Tomi-Pekka Mykkanen, Hannu M Poutanen, Kaisa S Raatikainen, Olavi J eng Randomized Controlled Trial Research Support, Non-U.S. Gov't 2016/05/18 Nutr Res. 2016 Jun; 36(6):612-9. doi: 10.1016/j.nutres.2016.02.008. Epub 2016 Feb 23"