| Title: | Volatile organic compounds as potential biomarkers of irritable bowel syndrome: A systematic review |
| Author(s): | Zhang VR; Ramachandran GK; Loo EXL; Soh AYS; Yong WP; Siah KTH; |
| Address: | "Department of Medicine, National University Hospital, Singapore, Singapore. Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore. Department of Paediatrics and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Division of Gastroenterology & Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore. Department of Haematology-Oncology, National University Cancer Institute, National University Health System, Singapore, Singapore" |
| ISSN/ISBN: | 1365-2982 (Electronic) 1350-1925 (Linking) |
| Abstract: | "BACKGROUND: Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disease characterized by intermittent abdominal pain with altered bowel habits. Due to the condition's chronicity, patients suffer from poor quality of life, while the healthcare burden continues to grow. There is currently no reliable biomarker for the diagnosis of IBS, and the current approach depends on ruling-out organic diseases such as inflammatory bowel disease (IBD) and colorectal cancer by markers of inflammation like fecal calprotectin and C-reactive protein, or invasive procedures like a colonoscopy. Volatile organic compounds (VOCs) are growing in popularity as a biomarker due to its accuracy and ease of use. PURPOSE: This systematic review of Medline and Cochrane's databases aimed to identify VOCs in the diagnosis of IBS. 57% of the studies proved that VOCs could identify IBS patients from healthy controls with AUC ranging from 0.83 to 0.99. Studies that distinguished IBS from IBD patients had slightly higher AUC of 0.87-0.98. Combining VOC into panels allowed the creation of discriminative algorithms. Though current research is limited by areas of heterogeneity in VOC sampling and small sample sizes, our review shows that VOC analysis has the potential to be a noninvasive point-of-care test that differentiates IBS from other organic gastrointestinal diseases" |
| Keywords: | "Humans *Irritable Bowel Syndrome/diagnosis *Volatile Organic Compounds/analysis/metabolism Quality of Life Diagnosis, Differential *Inflammatory Bowel Diseases/diagnosis Biomarkers/metabolism *Gastrointestinal Diseases/diagnosis Feces/chemistry biomarker;" |
| Notes: | "MedlineZhang, Valencia Ru-Yan Ramachandran, Gokula Krishnan Loo, Evelyn Xiu Ling Soh, Alex Yu Sen Yong, Wei Peng Siah, Kewin Tien Ho eng Review Systematic Review England 2023/02/14 Neurogastroenterol Motil. 2023 Jul; 35(7):e14536. doi: 10.1111/nmo.14536. Epub 2023 Feb 13" |
