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Biochem Med (Zagreb)

Title:		"Insights into cerumen and application in diagnostics: past, present and future prospective"
Author(s):		Shokry E; Filho NRA;
Address:		"Laboratorio de Metodos de Extracao e Separacao, Instituto de Quimica, Universidade Federal de Goias, Goiania, Brazil"
Journal Title:		Biochem Med (Zagreb)
Year:		2017
Volume:		27
Issue:		3
Page Number:		30503 -
DOI:		10.11613/BM.2017.030503
ISSN/ISBN:		1330-0962 (Print) 1846-7482 (Electronic) 1330-0962 (Linking)
Abstract:		"Cerumen or earwax is an emerging bio-fluid in clinical diagnosis that has been very little exploited during the past decades in spite of its high diagnostic potential. It is highly abundant in diagnostic biomarkers such as genetic material, lipids, proteins, chemical elements, internal and external metabolites (e.g. hormones, volatile organic compounds, amino acids, xenobiotics etc.) reaching earwax from the blood circulation. Thus, it is able to reflect not only physiology, pathophysiology of the human body but can also detect recent and long term exposure to environmental pollutants, without the need of invasive blood tests and in the same time overcoming many disadvantages faced by using other diagnostic biological fluids. This review discusses the biology, functions, chemistry of earwax, past and current approaches for the study of its chemical composition, emphasizing how a detected variation in its composition can offer information of high clinical value, which can be useful in diagnosis of many diseases such as metabolic disorders and tumours as well as in forensic applications. It also presents details about techniques of sample collection, storage, and analysis. Moreover, it highlights concerns about the use of earwax for diagnostic purposes, which should be addressed to make earwax diagnostics a reality in the future"
Keywords:		Biomarkers/chemistry/metabolism Cerumen/chemistry/*metabolism Diabetes Mellitus/diagnosis/metabolism Humans Metabolomics Parkinson Disease/diagnosis/metabolism Proteomics cerumen genomics laboratory diagnosis;
Notes:		"MedlineShokry, Engy Filho, Nelson Roberto Antoniosi eng Review Croatia 2017/11/29 Biochem Med (Zagreb). 2017 Oct 15; 27(3):030503. doi: 10.11613/BM.2017.030503"