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Sci Rep

Title:		"Volatile organic metabolites identify patients with breast cancer, cyclomastopathy, and mammary gland fibroma"
Author(s):		Wang C; Sun B; Guo L; Wang X; Ke C; Liu S; Zhao W; Luo S; Guo Z; Zhang Y; Xu G; Li E;
Address:		"Department of Anesthesiology, the First Affiliated Hospital of Harbin Medical University, Harbin, China. Department of Biostatistics, School of Public Health, Harbin Medical University, Harbin, China. CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China"
Journal Title:		Sci Rep
Year:		2014
Volume:		20140620
Issue:
Page Number:		5383 -
DOI:		10.1038/srep05383
ISSN/ISBN:		2045-2322 (Electronic) 2045-2322 (Linking)
Abstract:		"The association between cancer and volatile organic metabolites in exhaled breaths has attracted increasing attention from researchers. The present study reports on a systematic study of gas profiles of metabolites in human exhaled breath by pattern recognition methods. Exhaled breath was collected from 85 patients with histologically confirmed breast disease (including 39 individuals with infiltrating ductal carcinoma, 25 individuals with cyclomastopathy and from 21 individuals with mammary gland fibroma) and 45 healthy volunteers. Principal component analysis and partial least squares discriminant analysis were used to process the final data. The volatile organic metabolites exhibited significant differences between breast cancer and normal controls, breast cancer and cyclomastopathy, and breast cancer and mammary gland fibroma; 21, 6, and 8 characteristic metabolites played decisive roles in sample classification, respectively (P < 0.05). Three volatile organic metabolites in the exhaled air, 2,5,6-trimethyloctane, 1,4-dimethoxy-2,3-butanediol, and cyclohexanone, distinguished breast cancer patients from healthy individuals, mammary gland fibroma patients, and patients with cyclomastopathy (P < 0.05). The identified three volatile organic metabolites associated with breast cancer may serve as novel diagnostic biomarkers"
Keywords:		"Adult Biomarkers, Tumor/*metabolism Breast Neoplasms/diagnosis/*metabolism Breath Tests/*methods Carcinoma, Ductal, Breast/*metabolism Female Fibroma/*metabolism Humans Middle Aged Reproducibility of Results Sensitivity and Specificity Volatile Organic Co;"
Notes:		"MedlineWang, Changsong Sun, Bo Guo, Lei Wang, Xiaoyang Ke, Chaofu Liu, Shanshan Zhao, Wei Luo, Suqi Guo, Zhigang Zhang, Yang Xu, Guowang Li, Enyou eng Research Support, Non-U.S. Gov't England 2014/06/21 Sci Rep. 2014 Jun 20; 4:5383. doi: 10.1038/srep05383"