| Title: | Short-term exposure to dimethylformamide and the impact on digestive system disease: an outdoor study for volatile organic compound |
| Author(s): | Wang C; Huang C; Wei Y; Zhu Q; Tian W; Zhang Q; |
| Address: | "Department of Environmental Engineering, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Wenzhou Municipal of Environmental Monitoring Center Station, Wenzhou, China. Department of Environmental Engineering, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: qy_zhang@zju.edu.cn" |
| DOI: | 10.1016/j.envpol.2014.03.026 |
| ISSN/ISBN: | 1873-6424 (Electronic) 0269-7491 (Linking) |
| Abstract: | "Occupational and experimental studies have revealed the organs most affected by dimethylformamide (DMF) are liver and gastrointestinal tract. However, few studies have focused on the potential effect of outdoor pollution of DMF. This study examined the health risk of hospitalization due to digestive system disease by time series studies in a case city Longwan, China. The urine metabolite of DMF was correlated well with DMF exposure concentration (EC). A 101.0-mug/m(3) (interquartile range) increase in the two-day moving average of DMF EC was associated with a 1.10 (1.01 1.20), 1.22 (1.10 1.35), and 1.05 (0.90 1.22) increase in hospitalization for total digestive system diseases, liver disease, and gastrointestinal tract disease, respectively. The exposure-dose response between DMF and the relative risk of liver disease was linear only below 350 mug/m(3). These findings highlight a previously unrecognized health problem related to VOCs released into the outdoor environment" |
| Keywords: | Air Pollutants/metabolism/*toxicity Air Pollution/statistics & numerical data China Digestive System Diseases/chemically induced/*epidemiology/metabolism Dimethylformamide/metabolism/*toxicity Environmental Exposure/*analysis/statistics & numerical data H; |
| Notes: | "MedlineWang, Cui Huang, Canke Wei, Yumei Zhu, Qi Tian, Weili Zhang, Qingyu eng Research Support, Non-U.S. Gov't England 2014/04/22 Environ Pollut. 2014 Jul; 190:133-8. doi: 10.1016/j.envpol.2014.03.026. Epub 2014 Apr 18" |
