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Sci Rep

Title:		"Volatile Organic Metabolites Identify Patients with Mesangial Proliferative Glomerulonephritis, IgA Nephropathy and Normal Controls"
Author(s):		Wang C; Feng Y; Wang M; Pi X; Tong H; Wang Y; Zhu L; Li E;
Address:		"Department of Anesthesiology, the First Affiliated Hospital of Harbin Medical University, Harbin, China. Department of Nephrology, the First Affiliated Hospital of Harbin Medical University, Harbin, China"
Journal Title:		Sci Rep
Year:		2015
Volume:		20151007
Issue:
Page Number:		14744 -
DOI:		10.1038/srep14744
ISSN/ISBN:		2045-2322 (Electronic) 2045-2322 (Linking)
Abstract:		"Urinary volatile organic compounds (VOCs) analysis for kidney diseases has attracted a large amount of scientific interest recently, and urinary metabolite analysis has already been applied to many diseases. Urine was collected from 15 mesangial proliferative glomerulonephritis (MsPGN) patients, 21 IgA nephropathy (IgAN) patients and 15 healthy controls. Solid phase microextraction-chromatography- mass spectrometry (SPME-GC-MS) was used to analyse the urinary metabolites. The statistical methods principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLSDA) were performed to process the final data. Five metabolites were significantly greater in the group of MsPGN patients than in the normal control group (P < 0.05) while three metabolites were found at increased levels in the group of IgAN patients compared with the normal controls (P < 0.05). In addition, five metabolites were significantly increased in the group of IgAN patients compared with the MsPGN patients (P < 0.05). These five metabolites may be specific biomarkers for distinguishing between MsPGN and IgAN. The analysis of urinary VOCs appears to have potential clinical applications as a diagnostic tool"
Keywords:		"Adult Biomarkers/*metabolism Case-Control Studies Discriminant Analysis Female Gas Chromatography-Mass Spectrometry/methods Glomerular Mesangium/metabolism/*pathology Glomerulonephritis, IGA/*diagnosis/metabolism Glomerulonephritis, Membranoproliferative/;"
Notes:		"MedlineWang, Changsong Feng, Yue Wang, Mingao Pi, Xin Tong, Hongshuang Wang, Yue Zhu, Lin Li, Enyou eng Comparative Study Research Support, Non-U.S. Gov't England 2015/10/08 Sci Rep. 2015 Oct 7; 5:14744. doi: 10.1038/srep14744"