| Title: | Study of confounding factors influence on lung cancer diagnostics effectiveness using gas chromatography-mass spectrometry analysis of exhaled breath |
| Author(s): | Gashimova E; Osipova A; Temerdashev A; Porkhanov V; Polyakov I; Perunov D; Dmitrieva E; |
| Address: | "Department of Analytical Chemistry, Kuban State University, Krasnodar, Russia. Research Institute - Regional Clinical Hospital No. 1 named after Prof. SV Ochapovsky, Krasnodar, Russia" |
| ISSN/ISBN: | 1752-0371 (Electronic) 1752-0363 (Linking) |
| Abstract: | Aim: The purpose of this study was to estimate volatile organic compounds (VOCs) ability to distinguish exhaled breath samples of lung cancer patients and healthy volunteers and to assess the effect of smoking status and gender on parameters. Patients & methods: Exhaled breath samples of 40 lung cancer patients and 40 healthy individuals were analyzed using gas chromatography-mass spectrometry. Influence of other factors on the exhaled breath VOCs profile was investigated. Results: Some parameters correlating with the disease status were affected by other factors. Excluding these parameters allows creating a logistic regression diagnostic model with 83% sensitivity and 81% specificity. Conclusion: Influence of other factors on the exhaled breath VOCs profile has to be taken into account to avoid misleading results |
| Keywords: | *Gas Chromatography-Mass Spectrometry Gc-ms confounding factors exhaled breath lung cancer diagnostics volatile organic compounds; |
| Notes: | "MedlineGashimova, Elina Osipova, Anna Temerdashev, Azamat Porkhanov, Vladimir Polyakov, Igor Perunov, Dmitry Dmitrieva, Ekaterina eng Research Support, Non-U.S. Gov't England 2021/07/06 Biomark Med. 2021 Aug; 15(11):821-829. doi: 10.2217/bmm-2020-0828. Epub 2021 Jul 5" |
