| Title: | Selectivity of Exhaled Breath Biomarkers of Lung Cancer in Relation to Cancer of Other Localizations |
| Author(s): | Gashimova EM; Temerdashev AZ; Perunov DV; Porkhanov VA; Polyakov IS; Dmitrieva EV; |
| Address: | "Department of Analytical Chemistry, Kuban State University, Stavropol'skaya St. 149, Krasnodar 350040, Russia. Research Institute-Regional Clinical Hospital N degrees 1 n.a. Prof. S.V. Ochapovsky, 1 May St. 167, Krasnodar 350086, Russia" |
| ISSN/ISBN: | 1422-0067 (Electronic) 1422-0067 (Linking) |
| Abstract: | "Lung cancer is a leading cause of death worldwide, mostly due to diagnostics in the advanced stage. Therefore, the development of a quick, simple, and non-invasive diagnostic tool to identify cancer is essential. However, the creation of a reliable diagnostic tool is possible only in case of selectivity to other diseases, particularly, cancer of other localizations. This paper is devoted to the study of the variability of exhaled breath samples among patients with lung cancer and cancer of other localizations, such as esophageal, breast, colorectal, kidney, stomach, prostate, cervix, and skin. For this, gas chromatography-mass spectrometry (GC-MS) was used. Two classification models were built. The first model separated patients with lung cancer and cancer of other localizations. The second model classified patients with lung, esophageal, breast, colorectal, and kidney cancer. Mann-Whitney U tests and Kruskal-Wallis H tests were applied to identify differences in investigated groups. Discriminant analysis (DA), gradient-boosted decision trees (GBDT), and artificial neural networks (ANN) were applied to create the models. In the case of classifying lung cancer and cancer of other localizations, average sensitivity and specificity were 68% and 69%, respectively. However, the accuracy of classifying groups of patients with lung, esophageal, breast, colorectal, and kidney cancer was poor" |
| Keywords: | "Female Male Humans *Lung Neoplasms/diagnosis *Carcinoma, Renal Cell *Kidney Neoplasms Biomarkers *Colorectal Neoplasms Gc-ms cancer biomarkers diagnostics exhaled breath volatile organic compounds;" |
| Notes: | "MedlineGashimova, Elina M Temerdashev, Azamat Z Perunov, Dmitry V Porkhanov, Vladimir A Polyakov, Igor S Dmitrieva, Ekaterina V eng 22-13-20018/Russian Science Foundation and Kuban Scientific Foundation/ Switzerland 2023/09/09 Int J Mol Sci. 2023 Aug 28; 24(17):13350. doi: 10.3390/ijms241713350" |
