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Curr Opin Genet Dev

Title:		Pheromone signalling and polarized morphogenesis in yeast
Author(s):		Leberer E; Thomas DY; Whiteway M;
Address:		"NRC Biotechnology Research Institute, 6100 Royalmount Avenue, Montreal Quebec, Canada H4P 2R2"
Journal Title:		Curr Opin Genet Dev
Year:		1997
Volume:		7
Issue:		1
Page Number:		59 - 66
DOI:		10.1016/s0959-437x(97)80110-4
ISSN/ISBN:		0959-437X (Print) 0959-437X (Linking)
Abstract:		"Yeast cells respond to mating pheromones by activating a signal transduction pathway involving a seven transmembrane receptor/G protein complex linked to a mitogen-activated protein kinase module. Regulation of the G protein signal is controlled by the receptor and Sst2p; Sst2p may function as a GTPase-activating protein for the G protein alpha subunit. The Ste20 kinase acts in the linkage between the G protein and the MAP kinase module. Experiments suggest that binding of the Rho-like GTPase Cdc42p to Ste20p is not required for the mating response, yet is needed for the pseudohyphal growth response which involves many of the same kinases"
Keywords:		GTP-Binding Proteins/physiology Pheromones/*physiology Saccharomyces cerevisiae/*growth & development Signal Transduction/*physiology;
Notes:		"MedlineLeberer, E Thomas, D Y Whiteway, M eng Review England 1997/02/01 Curr Opin Genet Dev. 1997 Feb; 7(1):59-66. doi: 10.1016/s0959-437x(97)80110-4"