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Foodborne Pathog Dis

Title:		Presence of glycopeptide-encoding plasmids in enterococcal isolates from food and humans in Denmark
Author(s):		Garcia-Migura L; Sanchez-Valenzuela AJ; Jensen LB;
Address:		"National Food Institute, Division of Microbiology and Risk Assessment, Antimicrobial Resistance Unit, Technical University of Denmark, Lyngby, Denmark. lourdes.migura@cresa.uab.cat"
Journal Title:		Foodborne Pathog Dis
Year:		2011
Volume:		20110727
Issue:		11
Page Number:		1191 - 1197
DOI:		10.1089/fpd.2011.0897
ISSN/ISBN:		1556-7125 (Electronic) 1535-3141 (Linking)
Abstract:		"Enterococci and especially glycopeptides-resistant enterococci (GRE) are a growing concern due to their ability to cause infections in hospitals. Transmission of antimicrobial resistance between reservoirs such as animals, meat, and humans are in most cases linked to transmission of mobile genetic elements (MGE) such as plasmids and transposons. Presence of MGE was tested in all GRE isolated from food in Denmark in 2005-2007 including the first vanA mediated Enterococcus faecalis isolated from food. The ability of these plasmids to transfer and persist among enterococci was investigated using newly developed techniques for classification of plasmids. Replicons associated with sex pheromone-inducible plasmids were detected in all GR E. faecalis, whereas GR Enterococcus faecium contained plasmids known to be widely distributed among enterococci. vanA resistance is common in E. faecium isolates from meat and animals in Europe and is rarely found in E. faecalis. This article describes the first characterization of MGE from vanA mediated E. faecalis, thus linking this resistance genotype to pheromone responding plasmids"
Keywords:		Animals Anti-Bacterial Agents/*pharmacology Bacterial Proteins/*genetics Carbon-Oxygen Ligases/*genetics DNA Transposable Elements Denmark Enterococcus faecalis/drug effects/*genetics/isolation & purification Enterococcus faecium/drug effects/*genetics/is;
Notes:		"MedlineGarcia-Migura, Lourdes Sanchez-Valenzuela, Antonio J Jensen, Lars Bogo eng Research Support, Non-U.S. Gov't 2011/07/29 Foodborne Pathog Dis. 2011 Nov; 8(11):1191-7. doi: 10.1089/fpd.2011.0897. Epub 2011 Jul 27"