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Clin Exp Allergy

Title:		Priorities for future research into asthma diagnostic tools: A PAN-EU consensus exercise from the European asthma research innovation partnership (EARIP)
Author(s):		Garcia-Marcos L; Edwards J; Kennington E; Aurora P; Baraldi E; Carraro S; Gappa M; Louis R; Moreno-Galdo A; Peroni DG; Pijnenburg M; Priftis KN; Sanchez-Solis M; Schuster A; Walker S; Collaboration E;
Address:		"Respiratory and Allergy Units, Arrixaca University Children's Hospital, University of Murcia & IMIB Research Institute, Murcia, Spain. Asthma UK, London, UK. Department of Paediatric Respiratory Medicine, Great Ormond Street Hospital for Children, London, UK. Department of Respiratory, Critical Care and Anaesthesia Unit, University College London (UCL) Great Ormond Street Institute of Child Health, London, UK. Women's and Children's Health Department, University of Padua, Padova, Italy. Children's Hospital & Research Institute, Marienhospital Wesel, Wesel, Germany. Department of Respiratory Medicine, University of Liege, Liege, Belgium. Paediatric Pulmonology Unit, Hospital Vall d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain. Department of Clinical and Experimental Medicine, Section of Paediatrics, University of Pisa, Pisa, Italy. Paediatrics/Paediatric Respiratory Medicine, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands. Department of Paediatrics, Athens University Medical School, Attikon General Hospital, Athens, Greece. Department of Paediatrics, University Hospital, Dusseldorf, Germany"
Journal Title:		Clin Exp Allergy
Year:		2018
Volume:		48
Issue:		2
Page Number:		104 - 120
DOI:		10.1111/cea.13080
ISSN/ISBN:		1365-2222 (Electronic) 0954-7894 (Linking)
Abstract:		"The diagnosis of asthma is currently based on clinical history, physical examination and lung function, and to date, there are no accurate objective tests either to confirm the diagnosis or to discriminate between different types of asthma. This consensus exercise reviews the state of the art in asthma diagnosis to identify opportunities for future investment based on the likelihood of their successful development, potential for widespread adoption and their perceived impact on asthma patients. Using a two-stage e-Delphi process and a summarizing workshop, a group of European asthma experts including health professionals, researchers, people with asthma and industry representatives ranked the potential impact of research investment in each technique or tool for asthma diagnosis and monitoring. After a systematic review of the literature, 21 statements were extracted and were subject of the two-stage Delphi process. Eleven statements were scored 3 or more and were further discussed and ranked in a face-to-face workshop. The three most important diagnostic/predictive tools ranked were as follows: 'New biological markers of asthma (eg genomics, proteomics and metabolomics) as a tool for diagnosis and/or monitoring,' 'Prediction of future asthma in preschool children with reasonable accuracy' and 'Tools to measure volatile organic compounds (VOCs) in exhaled breath.'"
Keywords:		Asthma/*diagnosis Biomarkers Breath Tests Consensus Europe *Health Priorities Humans Metabolomics/methods Prognosis *Research Respiratory Function Tests;
Notes:		"MedlineGarcia-Marcos, L Edwards, J Kennington, E Aurora, P Baraldi, E Carraro, S Gappa, M Louis, R Moreno-Galdo, A Peroni, D G Pijnenburg, M Priftis, K N Sanchez-Solis, M Schuster, A Walker, S eng Research Support, Non-U.S. Gov't Review England 2018/01/01 Clin Exp Allergy. 2018 Feb; 48(2):104-120. doi: 10.1111/cea.13080"