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J Sci Food Agric

Title:		"Phytochemical screening, anticancer and antioxidant activities of Origanum vulgare L. ssp. viride (Boiss.) Hayek, a plant of traditional usage"
Author(s):		Koldas S; Demirtas I; Ozen T; Demirci MA; Behcet L;
Address:		"Department of Chemistry, Faculty of Natural Sciences, Cankiri Karatekin University, 18100, Cankiri, Turkey"
Journal Title:		J Sci Food Agric
Year:		2015
Volume:		20141016
Issue:		4
Page Number:		786 - 798
DOI:		10.1002/jsfa.6903
ISSN/ISBN:		1097-0010 (Electronic) 0022-5142 (Linking)
Abstract:		"BACKGROUND: A detailed phytochemical analysis of Origanum vulgare L. ssp. viride (Boiss.) Hayek was carried out and the antioxidant activities of five different crude extracts were determined. The antiproliferative activities of the extracts were determined using the xCELLigence system (Real Time Cell Analyzer). RESULTS: Differences between the essential oil and volatile organic compound profiles of the plant were shown. The main component of the essential oil was caryophyllene oxide, while the main volatile organic compounds were sabinene and eucalyptol as determined by HS-GC/MS. Phenolic contents of the extracts were determined qualitatively and quantitatively by HPLC/TOF-MS. Ten phenolic compounds were found in the extracts from O. vulgare and Origanum acutidens: rosmarinic acid (in highest abundance), chicoric acid, caffeic acid, p-coumaric acid, gallic acid, quercetin, apigenin-7-glucoside, kaempferol, naringenin and 4-hydroxybenzaldehyde. CONCLUSION: This study provides first results on the antiproliferative and antioxidant properties and detailed phytochemical screening of O. vulgare ssp. viride (Boiss.) Hayek"
Keywords:		"Antineoplastic Agents, Phytogenic/analysis/chemistry/*isolation & purification/pharmacology Antioxidants/analysis/chemistry/*isolation & purification/pharmacology Bicyclic Monoterpenes Cell Proliferation/drug effects Cyclohexanols/analysis/chemistry/isola;"
Notes:		"MedlineKoldas, Serkan Demirtas, Ibrahim Ozen, Tevfik Demirci, Mehmet Ali Behcet, Lutfi eng Research Support, Non-U.S. Gov't England 2014/09/10 J Sci Food Agric. 2015 Mar 15; 95(4):786-98. doi: 10.1002/jsfa.6903. Epub 2014 Oct 16"