| Title: | Estimating the potential impact of Attractive Targeted Sugar Baits (ATSBs) as a new vector control tool for Plasmodium falciparum malaria |
| Author(s): | Fraser KJ; Mwandigha L; Traore SF; Traore MM; Doumbia S; Junnila A; Revay E; Beier JC; Marshall JM; Ghani AC; Muller G; |
| Address: | "MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, UK. keith.fraser@imperial.ac.uk. MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, UK. Nuffield Department of Primary Care Health Science, University of Oxford, Oxford, UK. Malaria Research and Training Centre, Faculty of Medicine, Pharmacy and Odonto-Stomatology, University of Sciences, Techniques and Technology of Bamako, BP, Bamako, Mali. Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA. Division of Biostatistics and Epidemiology, School of Public Health, University of California, Berkeley, CA, USA" |
| DOI: | 10.1186/s12936-021-03684-4 |
| ISSN/ISBN: | 1475-2875 (Electronic) 1475-2875 (Linking) |
| Abstract: | "BACKGROUND: Attractive targeted sugar baits (ATSBs) are a promising new tool for malaria control as they can target outdoor-feeding mosquito populations, in contrast to current vector control tools which predominantly target indoor-feeding mosquitoes. METHODS: It was sought to estimate the potential impact of these new tools on Plasmodium falciparum malaria prevalence in African settings by combining data from a recent entomological field trial of ATSBs undertaken in Mali with mathematical models of malaria transmission. The key parameter determining impact on the mosquito population is the excess mortality due to ATSBs, which is estimated from the observed reduction in mosquito catch numbers. A mathematical model capturing the life cycle of P. falciparum malaria in mosquitoes and humans and incorporating the excess mortality was used to estimate the potential epidemiological effect of ATSBs. RESULTS: The entomological study showed a significant reduction of ~ 57% (95% CI 33-72%) in mosquito catch numbers, and a larger reduction of ~ 89% (95% CI 75-100%) in the entomological inoculation rate due to the fact that, in the presence of ATSBs, most mosquitoes do not live long enough to transmit malaria. The excess mortality due to ATSBs was estimated to be lower (mean 0.09 per mosquito per day, seasonal range 0.07-0.11 per day) than the bait feeding rate obtained from one-day staining tests (mean 0.34 per mosquito per day, seasonal range 0.28-0.38 per day). CONCLUSIONS: From epidemiological modelling, it was predicted that ATSBs could result in large reductions (> 30% annually) in prevalence and clinical incidence of malaria, even in regions with an existing high malaria burden. These results suggest that this new tool could provide a promising addition to existing vector control tools and result in significant reductions in malaria burden across a range of malaria-endemic settings" |
| Keywords: | "Animals Anopheles/*drug effects Malaria, Falciparum/*prevention & control Mali Models, Biological Mosquito Control/*methods Mosquito Vectors/*drug effects Pheromones/*pharmacology Sugars/*pharmacology Malaria Mosquito Vector control;" |
| Notes: | "MedlineFraser, Keith J Mwandigha, Lazaro Traore, Sekou F Traore, Mohamed M Doumbia, Seydou Junnila, Amy Revay, Edita Beier, John C Marshall, John M Ghani, Azra C Muller, Gunter eng MR/R015600/1/MRC_/Medical Research Council/United Kingdom U19 AI129387/AI/NIAID NIH HHS/ England 2021/03/19 Malar J. 2021 Mar 17; 20(1):151. doi: 10.1186/s12936-021-03684-4" |
