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PLoS One

Title:		Complex chemosensory control of female reproductive behaviors
Author(s):		Fraser EJ; Shah NM;
Address:		"Program in Genetics, Department of Anatomy, University of California San Francisco, San Francisco, California, United States of America"
Journal Title:		PLoS One
Year:		2014
Volume:		20140228
Issue:		2
Page Number:		e90368 -
DOI:		10.1371/journal.pone.0090368
ISSN/ISBN:		1932-6203 (Electronic) 1932-6203 (Linking)
Abstract:		"Olfaction exerts a profound influence on reproductive physiology and behavior in many animals, including rodents. Odors are recognized by sensory neurons residing in the main olfactory epithelium (MOE) and the vomeronasal organ (VNO) in mice and many other vertebrates. The relative contributions of the MOE and VNO in the display of female behaviors are not well understood. Mice null for Cnga2 or Trpc2 essentially lack odor-evoked activity in the MOE and VNO, respectively. Using females mutant for one or both of Cnga2 and Trpc2, we find that maternal care is differentially regulated by the MOE and VNO: retrieval of wandering pups requires the MOE and is regulated redundantly by the VNO whereas maternal aggression requires both sensory epithelia to be functional. Female sexual receptivity appears to be regulated by both the MOE and VNO. Trpc2 null females have previously been shown to display male-type mounting towards other males. Remarkably, we find that females double mutant for Cnga2 and Trpc2 continue to mount other males, indicating that the disinhibition of male-type sexual displays observed in Trpc2 null females does not require chemosensory input from a functional MOE. Taken together, our findings reveal a previously unappreciated complexity in the chemosensory control of reproductive behaviors in the female mouse"
Keywords:		"Aggression Animals Animals, Newborn Cyclic Nucleotide-Gated Cation Channels/deficiency/genetics Female Gene Expression Male Maternal Behavior Mice Mice, Knockout Neurons, Afferent/cytology/metabolism Odorants Olfactory Mucosa/*metabolism Pheromones/metabo;"
Notes:		"MedlineFraser, Eleanor J Shah, Nirao M eng R01 NS049488/NS/NINDS NIH HHS/ R01-NS049488/NS/NINDS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 2014/03/04 PLoS One. 2014 Feb 28; 9(2):e90368. doi: 10.1371/journal.pone.0090368. eCollection 2014"