| Title: | Structure-activity relationship studies on quorum sensing ComX(RO-E-2) pheromone |
| Author(s): | Okada M; Yamaguchi H; Sato I; Cho SJ; Dubnau D; Sakagami Y; |
| Address: | "Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan. okada-org@mail.tains.tohoku.ac,jp" |
| DOI: | 10.1016/j.bmcl.2006.12.070 |
| ISSN/ISBN: | 0960-894X (Print) 1464-3405 (Electronic) 0960-894X (Linking) |
| Abstract: | "The ComX pheromone is a posttranslationally modified oligopeptide that stimulates natural genetic competence in Bacillus subtilis. Various ComX(RO-E-2) analogs were synthesized and their biological activities were studied to investigate structure-activity relationships. These results showed that the minimal active unit was the tripeptide, [3-5]ComX(RO-E-2), and all residues except the modified tryptophan residue were replaceable by alanine without total loss of activity" |
| Keywords: | "Alanine/chemistry Amino Acid Substitution Bacillus/genetics Bacterial Proteins/biosynthesis/*chemistry/*pharmacology Chromatography, High Pressure Liquid Indicators and Reagents Lac Operon/genetics Mass Spectrometry Quorum Sensing/*drug effects Structure-;" |
| Notes: | "MedlineOkada, Masahiro Yamaguchi, Hisao Sato, Isao Cho, Soo Jeong Dubnau, David Sakagami, Youji eng R01 GM057720/GM/NIGMS NIH HHS/ R01 GM057720-38/GM/NIGMS NIH HHS/ GM 57720/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2007/01/24 Bioorg Med Chem Lett. 2007 Mar 15; 17(6):1705-7. doi: 10.1016/j.bmcl.2006.12.070. Epub 2006 Dec 23" |
