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Nat Chem Biol

Title:		Structure of the Bacillus subtilis quorum-sensing peptide pheromone ComX
Author(s):		Okada M; Sato I; Cho SJ; Iwata H; Nishio T; Dubnau D; Sakagami Y;
Address:		"Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan"
Journal Title:		Nat Chem Biol
Year:		2005
Volume:		20050524
Issue:		1
Page Number:		23 - 24
DOI:		10.1038/nchembio709
ISSN/ISBN:		1552-4450 (Print) 1552-4450 (Linking)
Abstract:		"The ComX pheromone is an extracellular signaling molecule that stimulates natural competence in response to crowding in the gram-positive bacterium Bacillus subtilis. The pheromone is formed by isoprenylation of an inactive precursor peptide, but its precise structure is not known. Here we report the structure of the ComX pheromone, showing that addition of a geranyl group to a tryptophan residue results in the formation of an unusual ring structure"
Keywords:		Amino Acid Sequence Bacillus subtilis/*metabolism Bacterial Proteins/biosynthesis/*chemistry Molecular Sequence Data Pheromones/biosynthesis/*chemistry Protein Conformation Tryptophan/chemistry;
Notes:		"MedlineOkada, Masahiro Sato, Isao Cho, Soo Jeong Iwata, Hidehisa Nishio, Toshihiko Dubnau, David Sakagami, Youji eng R01 GM057720/GM/NIGMS NIH HHS/ GM57720/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2006/01/13 Nat Chem Biol. 2005 Jun; 1(1):23-4. doi: 10.1038/nchembio709. Epub 2005 May 24"