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Nan Fang Yi Ke Da Xue Xue Bao

Title:		[Effects of cetylpyridinium chloride buccal tablets on halitosis induced by oral conditions]
Author(s):		Zhang D; Liu CH; Zhang J; Cai D; Yang X; Li S; Zhong H;
Address:		"epartment of Implantology, Affiliated Stomatological Hospital of Southern Medical University/Guangdong Provincial Stomatological Hospital, Guangzhou 510280, China. E-mail: 1194479077@qq.com"
Journal Title:		Nan Fang Yi Ke Da Xue Xue Bao
Year:		2014
Volume:		34
Issue:		9
Page Number:		1386 - 1389
DOI:
ISSN/ISBN:		1673-4254 (Print) 1673-4254 (Linking)
Abstract:		"OBJECTIVE: To investigate the effect of cetylpyridinium chloride buccal tablets on halitosis induced by oral conditions. METHODS: With Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum as the testing bacteria, the minimal inhibitory concentration (MIC) of cetylpyridinium chloride buccal tablets was determined using minute amount serial dilution test. The production of volatile sulfur compounds (VSCs) was measured using sulfide detector halimeter in the anaerobic bacteria culture at 4 and 8 h after addition of the tablets. The effect of the tablets in suppressing odor production by mouth-borne halitosis bacteria was assessed using cysteine challenge test in healthy volunteers, and the effectiveness was evaluated by measuring the reduction in VSCs production and the duration of the effect. RESULTS: Cetylpyridinium chloride buccal tablets inhibited the growth of all the 3 bacteria. The tablets obviously inhibited VSCs production by the 3 bacteria with a effect similar to chlorhexidine. Compared with distilled water gargle, the buccal tablets significantly reduced cysteine-induced VSCs production level in the healthy volunteers (P<0.05), and the effect lasted for 230 min. CONCLUSION: Cetylpyridinium chloride tablets can obviously suppress bacteria responsible for oral halitosis and produce good effects in the treatment of halitosis induced by oral conditions"
Keywords:		Cetylpyridinium/*therapeutic use Fusobacterium nucleatum/drug effects Halitosis/*drug therapy Humans Microbial Sensitivity Tests Porphyromonas gingivalis/drug effects Prevotella intermedia/drug effects Sulfur Compounds/analysis Tablets Volatile Organic Co;
Notes:		"MedlineZhang, Di Liu, Chang-Hong Zhang, Jincai Cai, Dehong Yang, Xiaoyu Li, Shiyi Zhong, Huilan chi Research Support, Non-U.S. Gov't China 2014/09/30 Nan Fang Yi Ke Da Xue Xue Bao. 2014 Aug; 34(9):1386-9"