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BMC Psychiatry
| Title: | Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA): A developmental cohort study protocol |
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| Author(s): | Sharma E; Vaidya N; Iyengar U; Zhang Y; Holla B; Purushottam M; Chakrabarti A; Fernandes GS; Heron J; Hickman M; Desrivieres S; Kartik K; Jacob P; Rangaswamy M; Bharath RD; Barker G; Orfanos DP; Ahuja C; Murthy P; Jain S; Varghese M; Jayarajan D; Kumar K; Thennarasu K; Basu D; Subodh BN; Kuriyan R; Kurpad SS; Kalyanram K; Krishnaveni G; Krishna M; Singh RL; Singh LR; Kalyanram K; Toledano M; Schumann G; Benegal V; VC; |
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| Address: | "Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India. eesha.250@gmail.com. Centre for Population Neuroscience and Precision Medicine, Institute of Psychology, Psychiatry & Neuroscience, MRC SGDP Centre, King's College London, London, UK. Department of Child & Adolescent Psychiatry, Institute of Psychology, Psychiatry & Neuroscience, King's College London, London, UK. Department of Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India. Molecular Genetics Laboratory, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India. Regional Occupational Health Centre (ROHC), Eastern, ICMR-National Institute of Occupational Health (NIOH), Kolkata, West Bengal, India. Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. Rishi Valley Rural Health Centre, Madanapalle, Chittoor, Andhra Pradesh, India. Department of Child and Adolescent Psychiatry, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India. Department of Psychology, Christ University, Bangalore, Karnataka, India. Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India. Department of Neuroimaging, Institute of Psychology, Psychiatry & Neuroscience, King's College London, London, UK. NeuroSpin, CEA, Universite Paris-Saclay, Paris, France. Department of Radiodiagnosis and Imaging, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Department of Mental Health and Clinical Psychology, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India. Department of Biostatistics, National Institute of Mental Health and Neuro-Sciences (NIMHANS), Bangalore, Karnataka, India. Department of Psychiatry, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Division of Nutrition, St John's Research Institute, Bengaluru, India. Department of Psychiatry & Department of Medical Ethics, St. John's Medical College & Hospital, Bengaluru, India. MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK. Epidemiology Research Unit, CSI Holdsworth Memorial Hospital, Mysore, India. Foundation for Research and Advocacy in Mental Health, Mysore, India. Department of Psychiatry, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, India. Department of Clinical Psychology, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur, India. Faculty of Medicine, School of Public Health, Imperial College, London, UK" |
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| Journal Title: | BMC Psychiatry |
| Year: | 2020 |
| Volume: | 20200102 |
| Issue: | 1 |
| Page Number: | 2 - |
| DOI: | 10.1186/s12888-019-2373-3 |
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| ISSN/ISBN: | 1471-244X (Electronic) 1471-244X (Linking) |
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| Abstract: | "BACKGROUND: Low and middle-income countries like India with a large youth population experience a different environment from that of high-income countries. The Consortium on Vulnerability to Externalizing Disorders and Addictions (cVEDA), based in India, aims to examine environmental influences on genomic variations, neurodevelopmental trajectories and vulnerability to psychopathology, with a focus on externalizing disorders. METHODS: cVEDA is a longitudinal cohort study, with planned missingness design for yearly follow-up. Participants have been recruited from multi-site tertiary care mental health settings, local communities, schools and colleges. 10,000 individuals between 6 and 23 years of age, of all genders, representing five geographically, ethnically, and socio-culturally distinct regions in India, and exposures to variations in early life adversity (psychosocial, nutritional, toxic exposures, slum-habitats, socio-political conflicts, urban/rural living, mental illness in the family) have been assessed using age-appropriate instruments to capture socio-demographic information, temperament, environmental exposures, parenting, psychiatric morbidity, and neuropsychological functioning. Blood/saliva and urine samples have been collected for genetic, epigenetic and toxicological (heavy metals, volatile organic compounds) studies. Structural (T1, T2, DTI) and functional (resting state fMRI) MRI brain scans have been performed on approximately 15% of the individuals. All data and biological samples are maintained in a databank and biobank, respectively. DISCUSSION: The cVEDA has established the largest neurodevelopmental database in India, comparable to global datasets, with detailed environmental characterization. This should permit identification of environmental and genetic vulnerabilities to psychopathology within a developmental framework. Neuroimaging and neuropsychological data from this study are already yielding insights on brain growth and maturation patterns" |
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| Keywords: | "Adolescent Behavior, Addictive/diagnostic imaging/*epidemiology/*psychology Child *Child Development/physiology Child, Preschool Cohort Studies Female Follow-Up Studies Humans India/epidemiology Infant Infant, Newborn Longitudinal Studies Male Mental Diso;" |
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| Notes: | "MedlineSharma, Eesha Vaidya, Nilakshi Iyengar, Udita Zhang, Yuning Holla, Bharath Purushottam, Meera Chakrabarti, Amit Fernandes, Gwen Sascha Heron, Jon Hickman, Matthew Desrivieres, Sylvane Kartik, Kamakshi Jacob, Preeti Rangaswamy, Madhavi Bharath, Rose Dawn Barker, Gareth Orfanos, Dimitri Papadopoulos Ahuja, Chirag Murthy, Pratima Jain, Sanjeev Varghese, Mathew Jayarajan, Deepak Kumar, Keshav Thennarasu, Kandavel Basu, Debashish Subodh, B N Kuriyan, Rebecca Kurpad, Sunita Simon Kalyanram, Kumaran Krishnaveni, Ghattu Krishna, Murali Singh, Rajkumar Lenin Singh, L Roshan Kalyanram, Kartik Toledano, Mireille Schumann, Gunter Benegal, Vivek eng MR/L022206/1/MRC_/Medical Research Council/United Kingdom MR/S019669/1/MRC_/Medical Research Council/United Kingdom ICMR/MRC-UK/3/M/2015-NCD-I/Indian Council of Medical Research/International MR/N000390/1/MRC_/Medical Research Council/United Kingdom Research Support, Non-U.S. Gov't England 2020/01/04 BMC Psychiatry. 2020 Jan 2; 20(1):2. doi: 10.1186/s12888-019-2373-3" |
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