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Nucleic Acids Res

Title:		"OlfactionBase: a repository to explore odors, odorants, olfactory receptors and odorant-receptor interactions"
Author(s):		Sharma A; Saha BK; Kumar R; Varadwaj PK;
Address:		"Department of Applied Science, Indian Institute of Information Technology, Allahabad, Uttar Pradesh 211015, India. Gentryx Technologies, West Bengal, Kolkata, India. Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, Uttar Pradesh 226028, India"
Journal Title:		Nucleic Acids Res
Year:		2022
Volume:		50
Issue:		D1
Page Number:		D678 - D686
DOI:		10.1093/nar/gkab763
ISSN/ISBN:		1362-4962 (Electronic) 0305-1048 (Print) 0305-1048 (Linking)
Abstract:		"Olfaction is a multi-stage process that initiates with the odorants entering the nose and terminates with the brain recognizing the odor associated with the odorant. In a very intricate way, the process incorporates various components functioning together and in synchronization. OlfactionBase is a free, open-access web server that aims to bring together knowledge about many aspects of the olfaction mechanism in one place. OlfactionBase contains detailed information of components like odors, odorants, and odorless compounds with physicochemical and ADMET properties, olfactory receptors (ORs), odorant- and pheromone binding proteins, OR-odorant interactions in Human and Mus musculus. The dynamic, user-friendly interface of the resource facilitates exploration of different entities: finding chemical compounds having desired odor, finding odorants associated with OR, associating chemical features with odor and OR, finding sequence information of ORs and related proteins. Finally, the data in OlfactionBase on odors, odorants, olfactory receptors, human and mouse OR-odorant pairs, and other associated proteins could aid in the inference and improved understanding of odor perception, which might provide new insights into the mechanism underlying olfaction. The OlfactionBase is available at https://bioserver.iiita.ac.in/olfactionbase/"
Keywords:		"Animals *Databases, Factual Humans Mice *Odorants Olfactory Receptor Neurons/*chemistry/metabolism Receptors, Odorant/chemistry/*genetics Signal Transduction/genetics Smell/genetics;"
Notes:		"MedlineSharma, Anju Saha, Bishal Kumar Kumar, Rajnish Varadwaj, Pritish Kumar eng Research Support, Non-U.S. Gov't England 2021/09/02 Nucleic Acids Res. 2022 Jan 7; 50(D1):D678-D686. doi: 10.1093/nar/gkab763"