| Title: | "17beta-Estradiol increases, aging decreases, c-Fos expression in the rat accessory olfactory bulb" |
| Author(s): | Balog JA; Kurunczi A; Parducz AA; |
| Address: | "Molecular Neurobiology Laboratory, Institute of Biophysics, Biological Research Center, 6701 Szeged, P.O. Box 521, Hungary" |
| DOI: | 10.1097/00001756-200112040-00037 |
| ISSN/ISBN: | 0959-4965 (Print) 0959-4965 (Linking) |
| Abstract: | "In the present paper we investigated the c-Fos immunoreactivity in the accessory olfactory bulb (AOB) of juvenile, adult and old rats of both sexes, as well as the effect of 17beta-estradiol on the expression of this immediate early gene. Basal c-Fos expression in the olfactory bulb decreased with age, and estrogen treatment caused an increase in the number of neurons expressing c-Fos in the AOB. The results indicate that both aging and estrogen have roles in the ability of neurons to co-ordinate genetic activity. Our observations may explain the decrease in age-related changes of brain plasticity, and provide data for the understanding of hormonally regulated neuronal plasticity" |
| Keywords: | "Aging/drug effects/*physiology Animals Cell Differentiation/drug effects/physiology Down-Regulation/drug effects/physiology Estradiol/*metabolism/pharmacology Female Gene Expression Regulation, Developmental/drug effects/physiology Immunohistochemistry Ma;" |
| Notes: | "MedlineBalog, J A Kurunczi, A Parducz A, A eng Research Support, Non-U.S. Gov't England 2001/12/01 Neuroreport. 2001 Dec 4; 12(17):3787-90. doi: 10.1097/00001756-200112040-00037" |
