| Title: | "Discriminant Profiles of Volatile Compounds in the Alveolar Air of Patients with Squamous Cell Lung Cancer, Lung Adenocarcinoma or Colon Cancer" |
| Author(s): | Politi L; Monasta L; Rigressi MN; Princivalle A; Gonfiotti A; Camiciottoli G; Perbellini L; |
| Address: | "Department of Clinical and Experimental Medicine, Careggi University Hospital, IT-50134 Florence, Italy. Institute for Maternal and Child Health-IRCCS Burlo Garofolo, IT-34137 Trieste, Italy. Occupational Medicine, Department of Diagnostics and Public Health, University of Verona, IT-37134 Verona, Italy" |
| DOI: | 10.3390/molecules26030550 |
| ISSN/ISBN: | 1420-3049 (Electronic) 1420-3049 (Linking) |
| Abstract: | "The objective of the present work was to analyze volatile compounds in alveolar air in patients with squamous cell lung cancer, lung adenocarcinoma or colon cancer, to prepare algorithms able to discriminate such specific pathological conditions. The concentration of 95 volatile com-pounds was measured in the alveolar air of 45 control subjects, 36 patients with lung adenocarci-noma, 25 patients with squamous cell lung cancer and 52 patients with colon cancer. Volatile compounds were measured with ion molecule reaction mass spectrometry (IMR-MS). An iterat-ed least absolute shrinkage and selection operator multivariate logistic regression model was used to generate specific algorithms and discriminate control subjects from patients with differ-ent kinds of cancer. The final predictive models reached the following performance: by using 11 compounds, patients with lung adenocarcinoma were identified with a sensitivity of 86% and specificity of 84%; nine compounds allowed us to identify patients with lung squamous cell car-cinoma with a sensitivity of 88% and specificity of 84%; patients with colon adenocarcinoma could be identified with a sensitivity of 96% and a specificity of 73% using a model comprising 13 volatile compounds. The different alveolar profiles of volatile compounds, obtained from pa-tients with three different kinds of cancer, suggest dissimilar biological-biochemistry condi-tions; each kind of cancer has probably got a specific alveolar profile" |
| Keywords: | "Adenocarcinoma of Lung/*metabolism Adult Aged Aged, 80 and over Breath Tests Carcinoma, Squamous Cell/*metabolism Colonic Neoplasms/*metabolism Female Humans Lung Neoplasms/*metabolism Male Middle Aged Pulmonary Alveoli/*metabolism *Volatile Organic Compo;" |
| Notes: | "MedlinePoliti, Leonardo Monasta, Lorenzo Rigressi, Maria Novella Princivalle, Andrea Gonfiotti, Alessandro Camiciottoli, Gianna Perbellini, Luigi eng Clinical Trial Switzerland 2021/01/27 Molecules. 2021 Jan 21; 26(3):550. doi: 10.3390/molecules26030550" |
