| Title: | Activating transcription factor 5 (ATF5) is essential for the maturation and survival of mouse basal vomeronasal sensory neurons |
| Author(s): | Nakano H; Iida Y; Suzuki M; Aoki M; Umemura M; Takahashi S; Takahashi Y; |
| Address: | "Laboratory of Environmental Molecular Physiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan. Laboratory of Environmental Molecular Physiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan. yuji@toyaku.ac.jp" |
| DOI: | 10.1007/s00441-015-2283-8 |
| ISSN/ISBN: | 1432-0878 (Electronic) 0302-766X (Linking) |
| Abstract: | "Activating transcription factor 5 (ATF5) is a member of the CREB/ATF family of transcription factors, which is highly expressed in olfactory chemosensory tissues, the main olfactory epithelium and vomeronasal epithelium (VNE) in mice. The vomeronasal sensory neurons in the VNE detect pheromones in order to regulate social behaviors such as mating and aggression; however, the physiological role of ATF5 in the vomeronasal sensory system remains unknown. In this study, we found that the differentiation of mature vomeronasal sensory neurons, assessed by olfactory marker protein expression, was inhibited in ATF5-deficient VNE. In addition, many apoptotic vomeronasal sensory neurons were evident in ATF5-deficient VNE. The vomeronasal sensory neurons consist of two major types of neuron expressing either vomeronasal 1 receptor (V1r)/Galphai2 or vomeronasal 2 receptor (V2r)/Galphao. We demonstrated that the differentiation, survival and axonal projection of V2r/Galphao-type rather than V1r/Galphai2-type vomeronasal sensory neurons were severely inhibited in ATF5-deficient VNE. These results suggest that ATF5 is one of the transcription factors crucial for the vomeronasal sensory formation" |
| Keywords: | "Activating Transcription Factors/*metabolism Animals Apoptosis *Cell Differentiation Cell Proliferation Cell Survival Epithelium/metabolism GTP-Binding Protein alpha Subunit, Gi2/metabolism GTP-Binding Protein alpha Subunits, Gi-Go/metabolism Gene Express;" |
| Notes: | "MedlineNakano, Haruo Iida, Yoshitaka Suzuki, Makoto Aoki, Marie Umemura, Mariko Takahashi, Shigeru Takahashi, Yuji eng Research Support, Non-U.S. Gov't Germany 2015/09/24 Cell Tissue Res. 2016 Mar; 363(3):621-33. doi: 10.1007/s00441-015-2283-8. Epub 2015 Sep 22" |
