« Previous Abstract"Effects of postnatal exposure to alcohol on reproductive physiology and sexually dimorphic behavior in a marsupial, the gray short-tailed opossum (Monodelphis domestica)"    Next AbstractA new monitoring approach for sustainability assessment of subsurface utilities gasket materials against gasoline and chlorinated solvents: Field evaluation and model development »

Eur J Pharm Biopharm

Title:		"Combined treatment of Thymus vulgaris L., Rosmarinus officinalis L. and Myrtus communis L. essential oils against Salmonella typhimurium: Optimization of antibacterial activity by mixture design methodology"
Author(s):		Fadil M; Fikri-Benbrahim K; Rachiq S; Ihssane B; Lebrazi S; Chraibi M; Haloui T; Farah A;
Address:		"Laboratory of Applied Organic Chemistry, Faculty of Sciences and Techniques Sidi Mohamed Ben Abdellah University, Fez, Morocco; Laboratory of Functional Ecology and Environment, Faculty of Sciences and Techniques Sidi Mohamed Ben Abdellah University, Fez, Morocco. Electronic address: fadil.mouhcine@gmail.com. Laboratory of Microbial Biotechnology, Faculty of Sciences and Techniques Sidi Mohamed Ben Abdellah University, Fez, Morocco. Laboratory of Functional Ecology and Environment, Faculty of Sciences and Techniques Sidi Mohamed Ben Abdellah University, Fez, Morocco. Laboratory of Applied Organic Chemistry, Faculty of Sciences and Techniques Sidi Mohamed Ben Abdellah University, Fez, Morocco"
Journal Title:		Eur J Pharm Biopharm
Year:		2018
Volume:		20170603
Issue:
Page Number:		211 - 220
DOI:		10.1016/j.ejpb.2017.06.002
ISSN/ISBN:		1873-3441 (Electronic) 0939-6411 (Linking)
Abstract:		"To increase the sensibility of Salmonella typhimurium strain, a mixture of Thymus vulgaris L. (T. vulgaris L.), Rosmarinus officinalis L. (R. officinalis L.) and Myrtus communis L. (M. communis L.) essential oils (EOs) was used in combined treatment by experimental design methodology (mixture design). The chemical composition of EOs was firstly identified by GC and GC/MS and their antibacterial activity was evaluated. The results of this first step have shown that thymol and borneol were the major compounds in T. vulgaris and M. communis L. EOs, respectively, while 1,8-cineole and alpha-pinene were found as major compounds in R. officinalis L. The same results have shown a strong antibacterial activity of T. vulgaris L. EO followed by an important power of M. communis L. EO against a moderate activity of R. officinalis L. EO. Besides, 1/20 (v/v) was the concentration giving a strain response classified as sensitive. From this concentration, the mixture design was performed and analyzed. The optimization of mixtures antibacterial activities has highlighted the synergistic effect between T. vulgaris L. and M. communis L. essential oils. A formulation comprising 55% of T. vulgaris L. and 45% of M. communis L. essential oils, respectively, can be considered for the increase of Salmonella typhimurium sensibility"
Keywords:		"Anti-Bacterial Agents/*administration & dosage/isolation & purification Chemistry, Pharmaceutical/methods Drug Therapy, Combination Microbial Sensitivity Tests/methods *Myrtus Oils, Volatile/*administration & dosage/isolation & purification Plant Componen;"
Notes:		"MedlineFadil, Mouhcine Fikri-Benbrahim, Kawtar Rachiq, Saad Ihssane, Bouchaib Lebrazi, Sara Chraibi, Marwa Haloui, Taoufik Farah, Abdellah eng Netherlands 2017/06/07 Eur J Pharm Biopharm. 2018 May; 126:211-220. doi: 10.1016/j.ejpb.2017.06.002. Epub 2017 Jun 3"