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Life Sci

Title:		Involvement of the corticoadrenal hormones in the pheromonal restoration of reproductive activity in aging rats
Author(s):		Mora OA; Sanchez-Criado JE;
Address:		"Departamento de Fisiologia, Facultad de Medicina, Universidad Complutense de Madrid. Av. Complutense s/n. 28040 Madrid, Spain. morano@med.ucm.es"
Journal Title:		Life Sci
Year:		2004
Volume:		74
Issue:		26
Page Number:		3285 - 3290
DOI:		10.1016/j.lfs.2003.11.015
ISSN/ISBN:		0024-3205 (Print) 0024-3205 (Linking)
Abstract:		"The involvement of the adrenal progesterone and corticosterone in the early gonadotropin secretion associated with the pheromonal restoration of ovarian cyclic activity (PRCA) in aging female rats is studied. PRCA is induced by male urinary pheromones and is preceded by an alpha-adrenergic-mediated release of the hypothalamic decapeptide luteinizing hormone-releasing hormone and plasma increases of estradiol, progesterone and the gonadotropins luteinizing hormone and follicle stimulating hormone. Aging reproductive Wistar female rats were used to study the effects of bilateral adrenalectomy and of a subcutaneous injection of the antisteroid RU486 on plasma levels of corticosterone, progesterone and gonadotropins in rats stimulated with nasal spraying of male urine (MU) or saline. The results demonstrate that progesterone and corticosterone released by MU are from adrenal origin, and that these adrenal secretory products are critical for MU-induced increase of gonadotropins. This suggests that olfactory stimulation of ACTH release stimulates adrenal release of progesterone and corticosterone, and both trigger the events that initiate the activation of the hypothalamus-pituitary-ovarian axis that leads to PRCA"
Keywords:		"Administration, Intranasal Adrenal Cortex Hormones/blood/*metabolism Adrenalectomy Aging/*metabolism Animals Corticosterone/blood/metabolism Estrous Cycle/*drug effects/metabolism Female Gonadotropins/blood/metabolism Male Progesterone/blood/metabolism Ra;"
Notes:		"MedlineMora, O A Sanchez-Criado, J E eng Research Support, Non-U.S. Gov't Netherlands 2004/04/20 Life Sci. 2004 May 14; 74(26):3285-90. doi: 10.1016/j.lfs.2003.11.015"