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J Vet Intern Med


Title:Effect of a Pheromone on Stress-Associated Reactivation of Feline Herpesvirus-1 in Experimentally Inoculated Kittens
Author(s):Contreras ET; Hodgkins E; Tynes V; Beck A; Olea-Popelka F; Lappin MR;
Address:"Center for Companion Animal Studies at Colorado State University, Fort Collins, CO. Ceva Animal Health, Lenexa, KS. Ceva Animal Health, Libourne, France"
Journal Title:J Vet Intern Med
Year:2018
Volume:20171208
Issue:1
Page Number:406 - 417
DOI: 10.1111/jvim.14894
ISSN/ISBN:1939-1676 (Electronic) 0891-6640 (Print) 0891-6640 (Linking)
Abstract:"BACKGROUND: Stress contributes to reactivation of feline herpesvirus-1 (FHV-1). The usage of pheromones to decrease stress in FHV-1 experimentally inoculated kittens has not previously been investigated. HYPOTHESIS/OBJECTIVES: To determine whether a feline pheromone would lessen stress, resulting in decreased recurrence of FHV-1-associated illness in kittens. ANIMALS: Twelve 5-month-old, purpose-bred kittens. METHODS: Randomized, double-blind, placebo-controlled clinical trial. Kittens previously infected with the same dose of FHV-1 were randomized into 2 separate but identical group rooms. After a 2-week equilibration period, a diffuser containing either the pheromone or placebo was placed in each of the rooms, and the kittens acclimated for an additional 2 weeks. Every 2 weeks thereafter, for the 8-week study period, housing was alternated between kennel- and group housing. Blinded observers applied a standardized clinical and behavioral scoring rubric daily. After each 2-week period, serum cortisol concentrations and quantitative PCR for FHV-1 and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) ratios were evaluated. Clinical, behavioral, and laboratory test results were compared between groups within individual and combined study periods. RESULTS: Sneezing occurred more frequently in the placebo group during individual (P = 0.006) and combined study periods (P = 0.001). Sleep at the end of observation periods occurred more frequently in the pheromone group during individual (P = 0.006) and combined study periods (P < 0.001). CONCLUSIONS AND CLINICAL IMPORTANCE: The findings suggest that the pheromone decreased stress, and the decrease in stress response may have resulted in decreased sneezing associated with FHV-1"
Keywords:"Animals Cat Diseases/pathology/*virology Cats Female Herpesviridae/physiology Herpesviridae Infections/drug therapy/pathology/*veterinary Housing, Animal Hydrocortisone/blood Male Pheromones/*pharmacology Sleep Sneezing Stress, Physiological/*physiology B;"
Notes:"MedlineContreras, Elena T Hodgkins, E Tynes, V Beck, A Olea-Popelka, F Lappin, M R eng Randomized Controlled Trial 2017/12/09 J Vet Intern Med. 2018 Jan; 32(1):406-417. doi: 10.1111/jvim.14894. Epub 2017 Dec 8"

 
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