« Previous AbstractImportance of enhanced mass resolution in removing interferences when measuring volatile organic compounds in human blood by using purge-and-trap gas chromatography/mass spectrometry    Next AbstractFecal descriptor in honey: indole from a floral source as an explanation »

J Anal Toxicol

Title:		Measurement of trihalomethanes and methyl tert-butyl ether in whole blood using gas chromatography with high-resolution mass spectrometry
Author(s):		Bonin MA; Silva LK; Smith MM; Ashley DL; Blount BC;
Address:		"Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA. mab2@cdc.gov"
Journal Title:		J Anal Toxicol
Year:		2005
Volume:		29
Issue:		2
Page Number:		81 - 89
DOI:		10.1093/jat/29.2.81
ISSN/ISBN:		0146-4760 (Print) 0146-4760 (Linking)
Abstract:		"The prevalence of disinfection by-products in drinking water supplies has raised concerns about possible adverse health effects from chronic exposure to these compounds. To support studies exploring the relation between exposure to trihalomethanes (THMs) and adverse health effects, an automated analytical method was developed using capillary gas chromatography (GC) and high-resolution mass spectrometry (MS) with selected ion mass detection and isotope-dilution techniques. This method quantified trace levels of THMs (including chloroform, bromodichloromethane, dibromochloromethane, and bromoform) and methyl tert-butyl ether (MTBE) in human blood. Analyte responses were adequate for measuring background levels after extraction of these volatile organic compounds with either purge-and-trap extraction or headspace solid-phase microextraction (SPME). The SPME method was chosen because of its ease of use and higher throughput. Detection limits for the SPME GC-MS method ranged from 0.3 to 2.4 ng/L, with linear ranges of three orders of magnitude. This method proved adequate for measuring the THMs and MTBE in most blood samples tested from a diverse U.S. reference population"
Keywords:		"Environmental Monitoring Gas Chromatography-Mass Spectrometry/*methods Humans Methyl Ethers/*blood Reproducibility of Results Trihalomethanes/*blood Water Pollutants, Chemical/*blood;"
Notes:		"MedlineBonin, Michael A Silva, Lalith K Smith, Mitchell M Ashley, David L Blount, Benjamin C eng Comparative Study Research Support, U.S. Gov't, Non-P.H.S. England 2005/05/21 J Anal Toxicol. 2005 Mar; 29(2):81-9. doi: 10.1093/jat/29.2.81"