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Biosci Biotechnol Biochem

Title:		Effect of environmental conditions on the alpha-glucosidase inhibitory activity of mulberry leaves
Author(s):		Nakanishi H; Onose S; Kitahara E; Chumchuen S; Takasaki M; Konishi H; Kanekatsu R;
Address:		"Satellite Venture Business Laboratory, Shinshu University, Ueda, Nagano, Japan"
Journal Title:		Biosci Biotechnol Biochem
Year:		2011
Volume:		20111207
Issue:		12
Page Number:		2293 - 2296
DOI:		10.1271/bbb.110407
ISSN/ISBN:		1347-6947 (Electronic) 0916-8451 (Linking)
Abstract:		"Mulberry leaves have been used as the sole food for silkworms in sericulture, and also as a traditional medicine for diabetes prevention. Mulberry leaf components, for example 1-deoxynojirimycin (1-DNJ), inhibit the activity of alpha-glucosidase and prevent increased blood glucose levels, and they are highly toxic to caterpillars other than silkworms. The alpha-glucosidase inhibitory activity of mulberry leaves changes with the season, but it is unknown which environmental conditions influence the alpha-glucosidase inhibitory activity. We investigated in this study the relationship between the alpha-glucosidase inhibitory activity and environmental conditions of temperature and photoperiod. The results demonstrate that low temperatures induced decreasing alpha-glucosidase inhibitory activity, while the induction of newly grown shoots by the scission of branches induced increasing alpha-glucosidase inhibitory activity. These results suggest that the alpha-glucosidase inhibitory activity was related to the defense mechanism of mulberry plants against insect herbivores"
Keywords:		1-Deoxynojirimycin/metabolism/pharmacology *Environment Enzyme Inhibitors/*pharmacology *Glycoside Hydrolase Inhibitors Morus/*chemistry/metabolism Photoperiod Plant Extracts/metabolism/*pharmacology Plant Leaves/*chemistry/metabolism Seasons;
Notes:		"MedlineNakanishi, Hiromitsu Onose, Shinji Kitahara, Eriko Chumchuen, Sukunya Takasaki, Midori Konishi, Hajime Kanekatsu, Rensuke eng Research Support, Non-U.S. Gov't England 2011/12/08 Biosci Biotechnol Biochem. 2011; 75(12):2293-6. doi: 10.1271/bbb.110407. Epub 2011 Dec 7"