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Curr Opin Microbiol

Title:		Self perception in bacteria: quorum sensing with acylated homoserine lactones
Author(s):		Fuqua C; Greenberg EP;
Address:		"Department of Biology, Trinity University, San Antonio, TX 78212, USA. cfuqua@trinity.edu"
Journal Title:		Curr Opin Microbiol
Year:		1998
Volume:		1
Issue:		2
Page Number:		183 - 189
DOI:		10.1016/s1369-5274(98)80009-x
ISSN/ISBN:		1369-5274 (Print) 1369-5274 (Linking)
Abstract:		"A variety of Gram-negative bacteria produce membrane permeant, acylated homoserine lactone (HL) pheromones that act as cell density cues. Synthesis and response to these factors requires proteins homologous to the Luxl acylhomoserine lactone synthase and the LuxR transcription factor from Vibrio fischeri. Recent genetic and biochemical studies have begun to provide a mechanistic understanding of acyl HL dependent gene regulation. Examination of the role of acyl HLs in diverse bacteria positions LuxR-Luxl type systems within an increasingly broad regulatory context and suggests that, in some bacteria, they comprise a global regulatory circuit"
Keywords:		"4-Butyrolactone/*analogs & derivatives/metabolism Acylation *Gene Expression Regulation, Bacterial Gram-Negative Bacteria/*genetics/*physiology Repressor Proteins/genetics Trans-Activators/genetics Transcriptional Activation;"
Notes:		"MedlineFuqua, C Greenberg, E P eng Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review England 1999/03/06 Curr Opin Microbiol. 1998 Apr; 1(2):183-9. doi: 10.1016/s1369-5274(98)80009-x"