| Title: | The calmodulin-binding transcription factor SIGNAL RESPONSIVE1 is a novel regulator of glucosinolate metabolism and herbivory tolerance in Arabidopsis |
| Author(s): | Laluk K; Prasad KV; Savchenko T; Celesnik H; Dehesh K; Levy M; Mitchell-Olds T; Reddy AS; |
| Address: | "Department of Biology, Colorado State University, Fort Collins, CO 80523, USA" |
| ISSN/ISBN: | 1471-9053 (Electronic) 0032-0781 (Print) 0032-0781 (Linking) |
| Abstract: | "The Arabidopsis Ca(2+)/calmodulin (CaM)-binding transcription factor SIGNAL RESPONSIVE1 (AtSR1/CAMTA3) was previously identified as a key negative regulator of plant immune responses. Here, we report a new role for AtSR1 as a critical component of plant defense against insect herbivory. Loss of AtSR1 function impairs tolerance to feeding by the generalist herbivore Trichoplusia ni as well as wound-induced jasmonate accumulation. The susceptibility of the atsr1 mutant is associated with decreased total glucosinolate (GS) levels. The two key herbivory deterrents, indol-3-ylmethyl (I3M) and 4-methylsulfinylbutyl (4MSOB), showed the most significant reductions in atsr1 plants. Further, changes in AtSR1 transcript levels led to altered expression of several genes involved in GS metabolism including IQD1, MYB51 and AtST5a. Overall, our results establish AtSR1 as an important component of plant resistance to insect herbivory as well as one of only three described proteins involved in Ca(2+)/CaM-dependent signaling to function in the regulation of GS metabolism, providing a novel avenue for future investigations of plant-insect interactions" |
| Keywords: | "Animals Arabidopsis/genetics/metabolism/*physiology Arabidopsis Proteins/genetics/*metabolism Calcium Signaling Calmodulin/metabolism Cyclopentanes/metabolism Disease Resistance Gene Expression Regulation, Plant Glucosinolates/*metabolism Herbivory Moths/;" |
| Notes: | "MedlineLaluk, K Prasad, K V S K Savchenko, T Celesnik, H Dehesh, K Levy, M Mitchell-Olds, T Reddy, A S N eng R01 GM086496/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Japan 2012/10/18 Plant Cell Physiol. 2012 Dec; 53(12):2008-15. doi: 10.1093/pcp/pcs143. Epub 2012 Oct 16" |
