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Fish Shellfish Immunol

Title:		"Effects of sodium butyrate and Lippia origanoides essential oil blend on growth, intestinal microbiota, histology, and haemato-immunological response of Nile tilapia"
Author(s):		Alves Jesus GF; Owatari MS; Pereira SA; Silva BC; Syracuse NM; Lopes GR; Addam K; Cardoso L; Pedreira Mourino JL; Martins ML;
Address:		"AQUOS - Aquatic Organisms Health Laboratory, Aquaculture Department, Federal University of Santa Catarina (UFSC), Rod. Admar Gonzaga 1346. CEP 88040-900, Florianopolis, SC, Brazil. AQUOS - Aquatic Organisms Health Laboratory, Aquaculture Department, Federal University of Santa Catarina (UFSC), Rod. Admar Gonzaga 1346. CEP 88040-900, Florianopolis, SC, Brazil. Electronic address: marco.owatari@ufsc.br. EPAGRI - Company of Agricultural Research and Rural Extension of Santa Catarina, Rod. Antonio Heil, 6800. CEP 88318-112, Itajai, SC, Brazil"
Journal Title:		Fish Shellfish Immunol
Year:		2021
Volume:		20210716
Issue:
Page Number:		62 - 69
DOI:		10.1016/j.fsi.2021.07.008
ISSN/ISBN:		1095-9947 (Electronic) 1050-4648 (Linking)
Abstract:		"This study aimed to verify the effects of dietary supplementation with sodium butyrate and Lippia origanoides, combined and isolated, on the health and zootechnical performance of Nile tilapia juveniles Oreochromis niloticus. A total of 120 fish (5.38 +/- 0.65 g) were randomly distributed in 12 experimental units and fed different experimental diets for 30 days, namely: commercial diet without supplementation (Unsupplemented); commercial diet supplemented with 0.5% sodium butyrate (Butyrate); commercial diet supplemented with 0.125% L. origanoides (Lippia) and commercial diet supplemented with a mixture of 0.5% sodium butyrate and 0.125% L. origanoides (Butyrate + Lippia). After preparing the experimental diets there was an increase in the pH of diet Butyrate when compared to the other diets. After 30 days the fish supplemented with Butyrate + Lippia showed reduction significate in the mean corpuscular haemoglobin, concentration of total heterotrophic bacteria in the intestine, and lymphocyte infiltrates in the liver. Besides that, the supplementation with Butyrate + Lippia promoted an increased number of intestinal villi compared to the fish Unsupplemented ones. Additionally, fish fed a diet containing only Lippia presented an increase in the villus perimeter in the posterior region of the gut and in the red blood cell number. Animals supplemented only with sodium butyrate demonstrated increased lactic acid bacterium in the gut and macrosteatosis in the liver, besides decreased melanomacrophages in the spleen. The use of sodium butyrate associated with essential oil had positive effects on the intestinal microbiota, intestinal structure, liver, and spleen integrity, suggesting a greater efficiency of the compounds when used together in the nutrition of Nile tilapia juveniles"
Keywords:		Animals Butyric Acid/*pharmacology *Cichlids/blood/growth & development/immunology/microbiology *Dietary Supplements Gastrointestinal Microbiome/drug effects Hematologic Tests *Lippia Liver/drug effects/immunology Lymphocytes/drug effects/immunology Macro;
Notes:		"MedlineAlves Jesus, Gabriel Fernandes Owatari, Marco Shizuo Pereira, Scheila Anelise Silva, Bruno Correa Syracuse, Nicholas Milis Lopes, Gustavo Ruschel Addam, Kennya Cardoso, Lucas Pedreira Mourino, Jose Luiz Martins, Mauricio Laterca eng Randomized Controlled Trial, Veterinary England 2021/07/20 Fish Shellfish Immunol. 2021 Oct; 117:62-69. doi: 10.1016/j.fsi.2021.07.008. Epub 2021 Jul 16"