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FEMS Microbiol Rev

Title:		Microbiota and fungal-bacterial interactions in the cystic fibrosis lung
Author(s):		Santos-Fernandez E; Martin-Souto L; Antoran A; Areitio M; Aparicio-Fernandez L; Bouchara JP; Schwarz C; Rementeria A; Buldain I; Ramirez-Garcia A;
Address:		"Department of Immunology, Microbiology and Parasitology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Barrio Sarriena s/n, 48940 Leioa, Spain. UNIV Angers, Universite de Bretagne Occidentale, Centre Hospitalier Universitaire (CHU) d'Angers, UR Infections Respiratoires Fongiques (IRF), Structure Federative de Recherche 'Interactions Cellulaires et Applications Therapeutiques (SFR ICAT), 49000 Angers, France. HMU-Health and Medical University Potsdam, Division Cystic Fibrosis, CF Center Westbrandenburg, Clinic Westbrandenburg, 14467 Potsdam, Germany"
Journal Title:		FEMS Microbiol Rev
Year:		2023
Volume:		47
Issue:		3
Page Number:		-
DOI:		10.1093/femsre/fuad029
ISSN/ISBN:		1574-6976 (Electronic) 0168-6445 (Linking)
Abstract:		"The most common genetic hereditary disease affecting Caucasians is cystic fibrosis (CF), which is caused by autosomal recessive mutations in the CFTR gene. The most serious consequence is the production of a thick and sticky mucus in the respiratory tract, which entraps airborne microorganisms and facilitates colonization, inflammation and infection. Therefore, the present article compiles the information about the microbiota and, particularly, the inter-kingdom fungal-bacterial interactions in the CF lung, the molecules involved and the potential effects that these interactions may have on the course of the disease. Among the bacterial compounds, quorum sensing-regulated molecules such as homoserine lactones, phenazines, rhamnolipids, quinolones and siderophores (pyoverdine and pyochelin) stand out, but volatile organic compounds, maltophilin and CF-related bacteriophages are also explained. These molecules exhibit diverse antifungal mechanisms, including iron starvation and induction of reactive oxygen and nitrogen species production. The fungal compounds are less studied, but they include cell wall components, siderophores, patulin and farnesol. Despite the apparent competition between microorganisms, the persistence of significant rates of bacterial-fungal co-colonization in CF suggests that numerous variables influence it. In conclusion, it is crucial to increase scientific and economic efforts to intensify studies on the bacterial-fungal inter-kingdom interactions in the CF lung"
Keywords:		Humans *Cystic Fibrosis/genetics/microbiology Siderophores Bacteria *Microbiota Lung/microbiology cystic fibrosis fungal and bacterial interaction inhibitory compounds inter-kingdom interaction lung microbiota quorum sensing;
Notes:		"MedlineSantos-Fernandez, Eneko Martin-Souto, Leire Antoran, Aitziber Areitio, Maialen Aparicio-Fernandez, Leire Bouchara, Jean-Philippe Schwarz, Carsten Rementeria, Aitor Buldain, Idoia Ramirez-Garcia, Andoni eng Research Support, Non-U.S. Gov't England 2023/06/08 FEMS Microbiol Rev. 2023 May 19; 47(3):fuad029. doi: 10.1093/femsre/fuad029"