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J Trace Elem Med Biol

Title:		Metal ion content of internal organs in the calorically restricted Wistar rat
Author(s):		Santos-Diaz AI; Solis-Lopez J; Diaz-Torres E; Guadarrama-Olmos JC; Osorio B; Kroll T; Webb SM; Hiriart M; Jimenez-Estrada I; Missirlis F;
Address:		"Department of Physiology, Biophysics and Neuroscience, Cinvestav, 07360 Mexico City, Mexico. Department of Physics, Cinvestav, 07360 Mexico City, Mexico. Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA. Institute of Cellular Physiology, National Autonomous University of Mexico, Mexico City 04510, Mexico. Department of Physiology, Biophysics and Neuroscience, Cinvestav, 07360 Mexico City, Mexico. Electronic address: fanis@fisio.cinvestav.mx"
Journal Title:		J Trace Elem Med Biol
Year:		2023
Volume:		20230428
Issue:
Page Number:		127182 -
DOI:		10.1016/j.jtemb.2023.127182
ISSN/ISBN:		1878-3252 (Electronic) 0946-672X (Linking)
Abstract:		"BACKGROUND: Despite the agreed principle that access to food is a human right, undernourishment and metal ion deficiencies are public health problems worldwide, exacerbated in impoverished or war-affected areas. It is known that maternal malnutrition causes growth retardation and affects behavioral and cognitive development of the newborn. Here we ask whether severe caloric restriction leads per se to disrupted metal accumulation in different organs of the Wistar rat. METHODS: Inductively coupled plasma optical emission spectroscopy was used to determine the concentration of multiple elements in the small and large intestine, heart, lung, liver, kidney, pancreas, spleen, brain, spinal cord, and three skeletal muscles from control and calorically restricted Wistar rats. The caloric restriction protocol was initiated from the mothers prior to mating and continued throughout gestation, lactation, and post-weaning up to sixty days of age. RESULTS: Both sexes were analyzed but dimorphism was rare. The pancreas was the most affected organ presenting a higher concentration of all the elements analyzed. Copper concentration decreased in the kidney and increased in the liver. Each skeletal muscle responded to the treatment differentially: Extensor Digitorum Longus accumulated calcium and manganese, gastrocnemius decreased copper and manganese, whereas soleus decreased iron concentrations. Differences were also observed in the concentration of elements between organs independently of treatment: The soleus muscle presents a higher concentration of Zn compared to the other muscles and the rest of the organs. Notably, the spinal cord showed large accumulations of calcium and half the concentration of zinc compared to brain. X-ray fluorescence imaging suggests that the extra calcium is attributable to the presence of ossifications whereas the latter finding is attributable to the low abundance of zinc synapses in the spinal cord. CONCLUSION: Severe caloric restriction did not lead to systemic metal deficiencies but caused instead specific metal responses in few organs"
Keywords:		"neuroscience;Rats Animals Male Female Humans Rats, Wistar *Copper *Manganese Calcium Zinc Muscle, Skeletal Biometals Calcium aggregates Inflammation Metallome Python code Synchrotron;"
Notes:		"MedlineSantos-Diaz, Alma I Solis-Lopez, Jordi Diaz-Torres, Elizabeth Guadarrama-Olmos, Jose C Osorio, Beatriz Kroll, Thomas Webb, Samuel M Hiriart, Marcia Jimenez-Estrada, Ismael Missirlis, Fanis eng Germany 2023/05/03 J Trace Elem Med Biol. 2023 Jul; 78:127182. doi: 10.1016/j.jtemb.2023.127182. Epub 2023 Apr 28"