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Animals (Basel)

Title:		From In Vitro Data to In Vivo Interspecies Danger Communication: A Study of Chemosensing via the Mouse Grueneberg Ganglion
Author(s):		Lopes AC; Brechbuhl J; Ferreira F; Amez-Droz M; Broillet MC;
Address:		"Department of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, Bugnon 27, CH-1011 Lausanne, Switzerland"
Journal Title:		Animals (Basel)
Year:		2022
Volume:		20220201
Issue:		3
Page Number:		-
DOI:		10.3390/ani12030356
ISSN/ISBN:		2076-2615 (Print) 2076-2615 (Electronic) 2076-2615 (Linking)
Abstract:		"In the wild, mice have developed survival strategies to detect volatile cues that warn them of potential danger. Specific olfactory neurons found in the Grueneberg ganglion olfactory subsystem can detect alarm pheromones emitted by stressed conspecifics, as well as kairomones involuntarily released by their predators. These volatile chemical cues allow intra- and interspecies communication of danger, respectively. Alarm pheromones, kairomones and bitter taste ligands share a common chemical motif containing sulfur or nitrogen. Interestingly, three specific bitter taste receptors (TAS2Rs) have been found in the Grueneberg ganglion neurons that are implicated in danger signalling pathways. We have recently developed a TAS2R-expressing heterologous system that mimics the Grueneberg ganglion neuron responses after kairomone stimulation. Here, we demonstrated by in vitro, ex vivo and in vivo experiments that the biological secretions from the raccoon (Procyon lotor) and the skunk (Mephitis mephitis) were acting as potent sources of kairomones. They activated the Grueneberg ganglion neurons and induced fear-related behaviours in mice. Identification of new sources of semiochemicals is a first step towards an understanding of the interspecies danger communication that takes place in the Grueneberg ganglion"
Keywords:		Grueneberg ganglion TAS2Rs chemical communication danger detection kairomones olfaction predators;
Notes:		"PubMed-not-MEDLINELopes, Ana Catarina Brechbuhl, Julien Ferreira, Flavio Amez-Droz, Marjorie Broillet, Marie-Christine eng 310030_185161/SNSF_/Swiss National Science Foundation/Switzerland Switzerland 2022/02/16 Animals (Basel). 2022 Feb 1; 12(3):356. doi: 10.3390/ani12030356"