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J Org Chem

Title:		Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source
Author(s):		Lopatka P; Markovic M; Koos P; Ley SV; Gracza T;
Address:		"Department of Organic Chemistry, Institute of Organic Chemistry, Catalysis and Petrochemistry , Slovak University of Technology , Radlinskeho 9 , SK-812 37 Bratislava , Slovakia. Georganics, Ltd. , Korenicova 1 , SK-811 03 Bratislava , Slovakia. Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , U.K"
Journal Title:		J Org Chem
Year:		2019
Volume:		20191029
Issue:		22
Page Number:		14394 - 14406
DOI:		10.1021/acs.joc.9b02453
ISSN/ISBN:		1520-6904 (Electronic) 0022-3263 (Linking)
Abstract:		"This work discloses a continuous flow carbonylation reaction using iron pentacarbonyl as source of CO. The described transformation using this surrogate was designed for use in commonly accessible flow equipment. Optimized conditions were applied to a scalable synthesis of the natural compound isolated from perianal glandular pheromone secretion of the African civet cat. In addition, a flow Pd-catalyzed carbonylation of aryl halides is successfully reported"
Keywords:
Notes:		"PubMed-not-MEDLINELopatka, Pavol Markovic, Martin Koos, Peter Ley, Steven V Gracza, Tibor eng Research Support, Non-U.S. Gov't 2019/10/28 J Org Chem. 2019 Nov 15; 84(22):14394-14406. doi: 10.1021/acs.joc.9b02453. Epub 2019 Oct 29"