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Ecotoxicol Environ Saf

Title:		"Association of long term exposure to outdoor volatile organic compounds (BTXS) with pro-inflammatory biomarkers and hematologic parameters in urban adults: A cross-sectional study in Tabriz, Iran"
Author(s):		Samadi MT; Shakerkhatibi M; Poorolajal J; Rahmani A; Rafieemehr H; Hesam M;
Address:		"Department of Environmental Health Engineering, Faculty of Health and Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: samadi@umsha.ac.ir. Health and Environment Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: shakerkhatibim@tbzmed.ac.ir. Research Center for Health Sciences and Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: poorolajal@umsha.ac.ir. Department of Environmental Health Engineering, Faculty of Health and Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: rahmani@umsha.ac.ir. Department of Medical Laboratory Sciences, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: rafee_1352@yahoo.com. Department of Environmental Health Engineering, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: mhesam66@gmail.com"
Journal Title:		Ecotoxicol Environ Saf
Year:		2019
Volume:		20190510
Issue:
Page Number:		152 - 159
DOI:		10.1016/j.ecoenv.2019.05.008
ISSN/ISBN:		1090-2414 (Electronic) 0147-6513 (Linking)
Abstract:		"This study aimed to compare the hematologic variables and pro-inflammatory biomarkers in urban adults living in Tabriz, Iran, facing various levels of outdoor volatile organic compounds (VOCs). Of all 219 people (212 male and 7 female), 71 were from the low traffic area and 148 were from high traffic and industrial areas. To validate the exposure levels, 93 air samples were taken to determine the target VOCs (benzene, toluene, xylenes, and styrene collectively called BTXS) concentrations in the studied areas. ANOVA and Tukey's tests were used for statistical analysis. Based on the results, significant differences were observed between the mean concentrations of BTXS with the following order of abundance: industrial?ª+>?ª+high traffic?ª+>?ª+low traffic. The Considerable decrease was observed in red blood cells (RBCs), hemoglobin, hematocrit, and eosinophils of 0.324 (?ª+x?ª+10(6)/muL), 0.57?ª+g/dL, 1.87%, and 0.17 (?ª+x?ª+10(3)/muL), respectively in industrial area participants as compared to the low traffic area. However, a significant increase was observed in white blood cell count (WBC), neutrophils number, neutrophils percent, TNF-alpha and INF-gamma of 0.88 (?ª+x?ª+10(3)/muL), 0.80 (?ª+x?ª+10(3)/muL), 3.53%, 34.2?ª+ng/mL, and 40.06?ª+ng/mL, respectively in the same groups. The comparison of low and high traffic areas showed significant differences in RBC (p?ª+=?ª+0.034), tumor necrosis factor alpha (TNF-alpha) (p?ª+
Keywords:		Adult Air Pollutants/*analysis Biomarkers/blood Cross-Sectional Studies Female Humans Inflammation Mediators/*blood Inhalation Exposure/*analysis Iran Male Urban Health Volatile Organic Compounds/*analysis Air pollution Hematologic parameters INF-gamma Ou;
Notes:		"MedlineSamadi, Mohammad Taghi Shakerkhatibi, Mohammad Poorolajal, Jalal Rahmani, Alireza Rafieemehr, Hassan Hesam, Mousa eng Comparative Study Netherlands 2019/05/15 Ecotoxicol Environ Saf. 2019 Sep 30; 180:152-159. doi: 10.1016/j.ecoenv.2019.05.008. Epub 2019 May 10"