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Cell

Title:		Tuning bulk electrostatics to regulate protein function
Author(s):		Serber Z; Ferrell JE;
Address:		"Department of Chemical and Systems Biology, Stanford University School of Medicine, MC 5174, Stanford, CA 94305, USA"
Journal Title:		Cell
Year:		2007
Volume:		128
Issue:		3
Page Number:		441 - 444
DOI:		10.1016/j.cell.2007.01.018
ISSN/ISBN:		0092-8674 (Print) 0092-8674 (Linking)
Abstract:		"Cyclin-dependent kinase activation can prevent yeast cells from responding to mating pheromone. Strickfaden et al. (2007) now show that this block arises from the multisite phosphorylation of Ste5. This provides a beautiful example of how phosphorylation can produce decisive changes in protein function through bulk electrostatics, without the necessity of intricate conformational changes"
Keywords:		"Adaptor Proteins, Signal Transducing/chemistry/*metabolism Cyclin-Dependent Kinases/*metabolism Cyclins/*metabolism Pheromones/metabolism Phosphorylation Saccharomyces cerevisiae/cytology/*metabolism Saccharomyces cerevisiae Proteins/chemistry/*metabolism;"
Notes:		"MedlineSerber, Zach Ferrell, James E Jr eng Comment 2007/02/10 Cell. 2007 Feb 9; 128(3):441-4. doi: 10.1016/j.cell.2007.01.018"