| Title: | Volatile Compounds Are Involved in Cellular Crosstalk and Upregulation |
| Author(s): | Serasanambati M; Broza YY; Haick H; |
| Address: | "Department of Chemical Engineering, Technion - Israel Institute of Technology, Technion City, Haifa, 3200003, Israel. Russell Berries Nanotechnology Institute, Technion - Israel Institute of Technology, Technion City, Haifa, 3200003, Israel. Technion Integrated Cancer Center, The Ruth and Bruce Rappaport Faculty of Medicine, 1-Efron St. Bat Galim, Haifa, 3525433, Israel" |
| ISSN/ISBN: | 2366-7478 (Print) 2366-7478 (Linking) |
| Abstract: | "Cell-cell cross talk is of great importance in cancer research due to its major role in proliferation, differentiation, migration, and influence on the apoptotic pathway. Different cell-cell communication mechanisms have come mainly from proteomic and genomic approaches. In this paper, a new route is reported for cross talk between cancer cells that occurs, even when they are far away from each other. Single-cell and culture analysis shows that upregulation of cancer cells emits hundreds of volatile organic compounds (VOCs) into their headspace. Part of the VOCs remains without any change, disregarding the biological environment around it. The other part of the VOCs is exchanged between monocultures of the cells as well as between co-cultures of the cells with no physical contact between them, leading to different changes in growth than when left on their own. The chemical nature and composition of these VOCs have been determined and are discussed herein. Cell-to-cell cross talk has the advantage of being suitable for transfer/diffusion over relatively long distances. It would thus be expected to serve as a shuttling pad toward the development of advanced approaches that could enable very early detection of cancer and/or monitoring of metastasis and related cancer therapy" |
| Keywords: | "Apoptosis/drug effects Cell Communication/*physiology Cell Line, Tumor Cell Proliferation/physiology Coculture Techniques Humans Signal Transduction/physiology Up-Regulation/*physiology Volatile Organic Compounds/*metabolism co-culture physical cell conta;" |
| Notes: | "MedlineSerasanambati, Mamatha Broza, Yoav Y Haick, Hossam eng Research Support, Non-U.S. Gov't Germany 2020/07/11 Adv Biosyst. 2019 Oct; 3(10):e1900131. doi: 10.1002/adbi.201900131. Epub 2019 Oct 3" |
