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Clin Ter

Title:		"Antioxidant properties of anesthetics: the biochemist, the surgeon and the anesthetist"
Author(s):		Li Volti G; Basile F; Murabito P; Galvano F; Di Giacomo C; Gazzolo D; Vadala S; Azzolina R; D'Orazio N; Mufeed H; Vanella L; Nicolosi A; Basile G; Biondi A;
Address:		"Department of Biological Chemistry, Medicinal Chemistry and Molecular Biology, University of CataniaCatania, Italy. livolti@unict.it"
Journal Title:		Clin Ter
Year:		2008
Volume:		159
Issue:		6
Page Number:		463 - 469
DOI:
ISSN/ISBN:		1972-6007 (Electronic) 0009-9074 (Linking)
Abstract:		"General anesthesia can impair immunological defense mechanisms while inducing an inflammatory reaction. Generalized inflammatory reactions involve leucocytes which in turn release inflammatory mediators and free oxygen radicals. General anesthetics include a series of gaseous and intravenous sedative-hypnotic agents indicated for induction and maintenance of general anesthesia as well as for sedation of intubated, mechanically ventilated adults in intensive care units (ICU). Some anesthetics, such as propofol, are characterized by a phenolic structure similar to that of alpha-tocopherol, and exhibit antioxidant properties that have been demonstrated both in vitro and in vivo. Similarly, other anesthetics show antioxidant and protective roles but this mechanism is to be related to their ability to induce antioxidant enzyme (i.e., heme oxygenase-1). The aim of the present review is to evaluate the antioxidant properties of anesthetics in various experimental models and if they may be considered efficient therapeutic tools in counteracting oxidative stress during general anesthesia and sedation in ICU"
Keywords:		"Adult Anesthetics, General/adverse effects/*chemistry/classification/pharmacology Antioxidants/*pharmacology Astrocytes/drug effects Cells, Cultured/drug effects Desflurane Enzyme Induction/drug effects Heme Oxygenase-1/antagonists & inhibitors/biosynthes;"
Notes:		"MedlineLi Volti, G Basile, F Murabito, P Galvano, F Di Giacomo, C Gazzolo, D Vadala, S Azzolina, R D'Orazio, N Mufeed, H Vanella, L Nicolosi, A Basile, G Biondi, A eng Review Italy 2009/01/27 Clin Ter. 2008 Nov-Dec; 159(6):463-9"