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Physiol Behav

Title:		Role of the ventromedial nucleus of hypothalamus in the male-induced enhancement of lordosis in female rats
Author(s):		Rajendren G; Dudley CA; Moss RL;
Address:		"Department of Physiology, University of Texas Southwestern Medical Center, Dallas 75235-9040"
Journal Title:		Physiol Behav
Year:		1991
Volume:		50
Issue:		4
Page Number:		705 - 710
DOI:		10.1016/0031-9384(91)90006-a
ISSN/ISBN:		0031-9384 (Print) 0031-9384 (Linking)
Abstract:		"The involvement of the ventromedial nucleus of the hypothalamus (VMH) in the mating-induced enhancement of lordosis in ovariectomized estrogen-primed rats was investigated. In the first experiment, females with bilateral VMH or sham lesions were primed with 2 micrograms estradiol benzoate, and 48 h later they were subjected to repeated-mating tests. The VMH-lesioned rats failed to exhibit lordosis during the tests; however, the sham-operated females exhibited a gradual increase in lordosis quotient (LQ) with repetitive matings. In the second experiment, ovariectomized females were bilaterally implanted with estradiol (E2) or cholesterol (C) in the VMH, 48 h prior to behavioral testing. Repeated-mating-induced elevation in LQ was observed in the females when they were bilaterally implanted with E2 in the VMH; C was ineffective. To exclude the possibility of the spread of E2 to areas adjacent to VMH, plasma-luteinizing hormone (LH) was measured. Elevation in the circulating LH levels following ovariectomy was not suppressed in the females following bilateral E2 implants in the VMH, suggesting that the effect of estrogen is localized within or immediately around the VMH. The results suggest that the integrity of the VMH is critical for the potentiation of lordosis behavior in ovariectomized estrogen-primed females by male-originating sensory cues, and that selective priming of the VMH with estrogen is sufficient for the male-induced enhancement of lordosis"
Keywords:		"Animals Arousal/*physiology Brain Mapping Chemoreceptor Cells/*physiology Dominance, Cerebral/physiology Estrogens/*physiology Female Nasal Mucosa/*innervation Ovariectomy Progesterone/*physiology Rats Rats, Inbred Strains Sex Attractants/physiology Sexua;"
Notes:		"MedlineRajendren, G Dudley, C A Moss, R L eng HD09988/HD/NICHD NIH HHS/ MH41784/MH/NIMH NIH HHS/ Research Support, U.S. Gov't, P.H.S. 1991/10/01 Physiol Behav. 1991 Oct; 50(4):705-10. doi: 10.1016/0031-9384(91)90006-a"