| Title: | Neuroendocrine responsiveness to oestradiol and male urine in neonatally androgenized prairie voles (Microtus ochrogaster) |
| Author(s): | Smale L; Nelson RJ; Zucker I; |
| ISSN/ISBN: | 0022-4251 (Print) 0022-4251 (Linking) |
| Abstract: | "The influence of neonatal androgenization on behavioural receptivity was tested by treating female voles on the 3rd day of life with testosterone propionate or with the oil vehicle. After treatment in adulthood with urine or with oestradiol benzoate, androgenized voles were less likely than normal females to display behavioural oestrus and were more likely to engage in agonistic behaviour in tests with stud males. Uteri of androgenized and control females treated with oestradiol benzoate in adulthood manifested similar increases in weight; however, only normal females treated with male urine showed increased uterine weights. Males castrated in adulthood did not display lordosis after treatment with oestradiol benzoate. Sexual differentiation induced by neonatal testicular secretions appears to limit responsiveness of the adult neuroendocrine axis to chemosensory stimuli in male urine" |
| Keywords: | "Animals Arvicolinae Estradiol/*pharmacology Estrus/drug effects Female Male Orchiectomy Organ Size Ovariectomy Pheromones/*physiology Sex Attractants/*physiology *Sex Differentiation *Sexual Behavior, Animal/drug effects Testosterone/pharmacology Uterus/a;" |
| Notes: | "MedlineSmale, L Nelson, R J Zucker, I eng HD-02982/HD/NICHD NIH HHS/ MH-15860/MH/NIMH NIH HHS/ Research Support, U.S. Gov't, P.H.S. England 1985/07/01 J Reprod Fertil. 1985 Jul; 74(2):491-6. doi: 10.1530/jrf.0.0740491" |
