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Eur J Neurosci

Title:		Accessory olfactory bulb function is modulated by input from the main olfactory epithelium
Author(s):		Slotnick B; Restrepo D; Schellinck H; Archbold G; Price S; Lin W;
Address:		"Department of Psychology, University of South Florida, PCD 4118G, 4202 Fowler Avenue, Tampa, FL 33620, USA. slotnic@american.edu"
Journal Title:		Eur J Neurosci
Year:		2010
Volume:		20100308
Issue:		6
Page Number:		1108 - 1116
DOI:		10.1111/j.1460-9568.2010.07141.x
ISSN/ISBN:		1460-9568 (Electronic) 0953-816X (Print) 0953-816X (Linking)
Abstract:		"Although it is now established that sensory neurons in both the main olfactory epithelium and the vomeronasal organ may be activated by both general and pheromonal odorants, it remains unclear what initiates sampling by the vomeronasal organ. Anterograde transport of wheat germ agglutinin-horseradish peroxidase was used to determine that adequate intranasal syringing with zinc sulfate interrupted all inputs to the main olfactory bulb but left intact those to the accessory olfactory bulb. Adult male treated mice were frankly anosmic when tested with pheromonal and non-pheromonal odors and failed to engage in aggressive behavior. Treated juvenile females failed to show puberty acceleration subsequent to exposure to bedding from adult males. Activation of the immediate early gene c-Fos and electrovomeronasogram recording confirmed the integrity of the vomeronasal system in zinc sulfate-treated mice. These results support the hypothesis that odor detection by the main olfactory epithelium is required to initiate sampling by the vomeronasal system"
Keywords:		"Age Factors Aggression/physiology Analysis of Variance Animals Animals, Newborn Behavior, Animal Discrimination, Psychological/drug effects Female Male Mice Mice, Inbred C57BL Neural Pathways/drug effects/physiology Odorants Olfactory Bulb/drug effects/*p;"
Notes:		"MedlineSlotnick, Burton Restrepo, Diego Schellinck, Heather Archbold, Georgina Price, Stephen Lin, Weihong eng P30 DC004657/DC/NIDCD NIH HHS/ DC004657/DC/NIDCD NIH HHS/ DC006070/DC/NIDCD NIH HHS/ DC04671/DC/NIDCD NIH HHS/ R01 DC004671/DC/NIDCD NIH HHS/ R01 DC009269-02/DC/NIDCD NIH HHS/ R01 DC006070/DC/NIDCD NIH HHS/ R01 DC009269/DC/NIDCD NIH HHS/ DC009269/DC/NIDCD NIH HHS/ R03 DC006828/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't France 2010/04/10 Eur J Neurosci. 2010 Mar; 31(6):1108-16. doi: 10.1111/j.1460-9568.2010.07141.x. Epub 2010 Mar 8"