| Title: | Ultra-Fast Portable and Wearable Sensing Design for Continuous and Wide-Spectrum Molecular Analysis and Diagnostics |
| Author(s): | Maity A; Milyutin Y; Maidantchik VD; Pollak YH; Broza Y; Omar R; Zheng Y; Saliba W; Huynh TP; Haick H; |
| Address: | "Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, Haifa, 3200003, Israel. Laboratory of Molecular Science and Engineering, Faculty of Science and Engineering, Abo Akademi University, Henrikinkatu 2, Turku, FI-20500, Finland" |
| ISSN/ISBN: | 2198-3844 (Electronic) 2198-3844 (Linking) |
| Abstract: | "The design and characterization of spatiotemporal nano-/micro-structural arrangement that enable real-time and wide-spectrum molecular analysis is reported and demonestrated in new horizons of biomedical applications, such as wearable-spectrometry, ultra-fast and onsite biopsy-decision-making for intraoperative surgical oncology, chiral-drug identification, etc. The spatiotemporal sesning arrangement is achieved by scalable, binder-free, functionalized hybrid spin-sensitive (< upward arrow| or < downward arrow|) graphene-ink printed sensing layers on free-standing films made of porous, fibrous, and naturally helical cellulose networks in hierarchically stacked geometrical configuration (HSGC). The HSGC operates according to a time-space-resolved architecture that modulate the mass-transfer rate for separation, eluation and detection of each individual compound within a mixture of the like, hereby providing a mass spectrogram. The HSGC could be used for a wide range of applictions, including fast and real-time spectrogram generator of volatile organic compounds during liquid-biopsy, without the need of any immunochemistry-staining and complex power-hungry cryogenic machines; and wearable spectrometry that provide spectral signature of molecular profiles emiited from skin in the course of various dietry conditions" |
| Keywords: | *Immunochemistry Spectrum Analysis breast cancer chiral molecules hierarchical electronics molecular analysis sensors spectromerty volatile organic compound wearable devices; |
| Notes: | "MedlineMaity, Arnab Milyutin, Yana Maidantchik, Vivian Darsa Pollak, Yael Hershkovitz Broza, Yoav Omar, Rawan Zheng, Youbin Saliba, Walaa Huynh, Tan-Phat Haick, Hossam eng Hittman Family Fund/ Research Support, Non-U.S. Gov't Germany 2022/10/22 Adv Sci (Weinh). 2022 Dec; 9(34):e2203693. doi: 10.1002/advs.202203693. Epub 2022 Oct 20" |
