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Spectrochim Acta A Mol Biomol Spectrosc

Title:		Standard operating procedure to reveal prostate cancer specific volatile organic molecules by infrared spectroscopy
Author(s):		Maiti KS; Fill E; Strittmatter F; Volz Y; Sroka R; Apolonski A;
Address:		"Max-Planck-Institut fur Quantenoptik, Hans-Kopfermann-Strasse 1, 85748 Garching, Germany; Lehrstuhl fur Experimental Physik, Ludwig-Maximilians-Universitat Munchen, Am Couombwall 1, 85748 Garching, Germany; Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, Garching, 85747, Germany; Department of Anesthesiology and Intensive Care Medicine/Center for Sepsis Control and Care, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany. Electronic address: kiran.maiti@mpq.mpg.de. Max-Planck-Institut fur Quantenoptik, Hans-Kopfermann-Strasse 1, 85748 Garching, Germany; Lehrstuhl fur Experimental Physik, Ludwig-Maximilians-Universitat Munchen, Am Couombwall 1, 85748 Garching, Germany. Urologische Klinik und Poliklinik des Klinikums der Ludwig-Maximilians- Universitat Munchen in Grosshadern, 81377 Munich, Germany. Urologische Klinik und Poliklinik des Klinikums der Ludwig-Maximilians- Universitat Munchen in Grosshadern, 81377 Munich, Germany; Laser-Forschungslabor, LIFE Center, University Hospital, Ludwig-Maximilians-Universitat Munchen, 82152 Planegg, Germany. Max-Planck-Institut fur Quantenoptik, Hans-Kopfermann-Strasse 1, 85748 Garching, Germany; Lehrstuhl fur Experimental Physik, Ludwig-Maximilians-Universitat Munchen, Am Couombwall 1, 85748 Garching, Germany; Institute of Automation and Electrometry SB RAS, 630090 Novosibirsk, Russia"
Journal Title:		Spectrochim Acta A Mol Biomol Spectrosc
Year:		2023
Volume:		20230822
Issue:
Page Number:		123266 -
DOI:		10.1016/j.saa.2023.123266
ISSN/ISBN:		1873-3557 (Electronic) 1386-1425 (Linking)
Abstract:		"The growing number of prostate cancer cases is a real concern in modern society. Over 1.4 million new cases and about 400 thousand (>26%) deaths were registered worldwide in 2020 due to prostate cancer. The high mortality rate of prostate cancer is due to the lack of reliable early detection of the disease. Till now the most reliable diagnosis of cancer is tissue biopsy, which is an invasive process. A non-invasive or minimally invasive technique could lead to a diagnostic tool that will allow for saving or prolonging the lifespan of millions of lives. Metabolite-based diagnostics may have a better chance of early cancer detection. However, reliable detection techniques need to be developed. Infrared spectroscopy based gaseous-biofluid holds great promise towards the development of non-invasive diagnostics. A pilot study based on breath analysis by infrared spectroscopy showed promising results in distinguishing prostate cancer patients from healthy volunteers. Details of the spectral metabolic analysis are presented"
Keywords:		Biomarker Breath analysis Component analysis Infrared spectroscopy Prostate cancer Spectral fingerprint Volatile organic compound (VOC);
Notes:		"PublisherMaiti, Kiran Sankar Fill, Ernst Strittmatter, Frank Volz, Yannic Sroka, Ronald Apolonski, Alexander eng England 2023/09/02 Spectrochim Acta A Mol Biomol Spectrosc. 2023 Aug 22; 304:123266. doi: 10.1016/j.saa.2023.123266"