| Title: | QSAR models for Daphnia magna toxicity prediction of benzoxazinone allelochemicals and their transformation products |
| Author(s): | Lo Piparo E; Fratev F; Lemke F; Mazzatorta P; Smiesko M; Fritz JI; Benfenati E; |
| Address: | "Istituto di Ricerche Farmacologiche 'Mario Negri' Milano, Via Eritrea 62, 20157 Milano, Italy" |
| ISSN/ISBN: | 0021-8561 (Print) 0021-8561 (Linking) |
| Abstract: | "The overall objective of this study is the ecotoxicological characterization of the benzoxazinone 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA), the benzoxazolinones benzoxazolin-2-one (BOA) and 6-methoxybenzoxazolin-2-one (MBOA), and their transformation products: phenoxazinones 2-acetylamino-7-methoxy-3H-phenoxazin-3-one (AAMPO), 2-acetylamino-3H-phenoxazin-3-one (AAPO), 2-amino-7-methoxy-3H-phenoxazin-3-one (AMPO), and 2-amino-3H-phenoxazin-3-one (APO); aminophenol 2-aminophenol AP); acetamide N-(2-hydroxyphenyl)acetamide (HPAA); and malonamic acid amide N-(2-hydroxyphenyl)malonamic acid (HPMA). A comparison between empirical results and theoretical ones using rules-based prediction of toxicity was done, and it can be concluded that only the degradation metabolites exhibited significant ecotoxic effect. Using synthetic pesticides knowledge, several QSAR models were trained with various approaches and descriptors. The models generated exhibited good internal predictive ability (R(cv)2 > 0.6) and were used to predict the toxicity of the natural compounds studied" |
| Keywords: | Animals Benzoxazines Benzoxazoles/chemistry/*metabolism/*toxicity Daphnia/*drug effects Oxazines/chemistry/metabolism/*toxicity Pheromones/*toxicity Quantitative Structure-Activity Relationship Triticum/chemistry; |
| Notes: | "MedlineLo Piparo, Elena Fratev, Filip Lemke, Frank Mazzatorta, Paolo Smiesko, Martin Fritz, Jona Ines Benfenati, Emilio eng Research Support, Non-U.S. Gov't 2006/02/16 J Agric Food Chem. 2006 Feb 22; 54(4):1111-5. doi: 10.1021/jf050918f" |
