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Biosens Bioelectron

Title:		Volatile general anesthetic sensing with organic field-effect transistors integrating phospholipid membranes
Author(s):		Daniela Angione M; Magliulo M; Cotrone S; Mallardi A; Altamura D; Giannini C; Cioffi N; Sabbatini L; Gobeljic D; Scamarcio G; Palazzo G; Torsi L;
Address:		"Dipartimento di Chimica, Universita degli Studi di Bari Aldo Moro, 70126 Bari, Italy. angione@chimica.uniba.it"
Journal Title:		Biosens Bioelectron
Year:		2013
Volume:		20120810
Issue:		1
Page Number:		303 - 307
DOI:		10.1016/j.bios.2012.07.068
ISSN/ISBN:		1873-4235 (Electronic) 0956-5663 (Linking)
Abstract:		"The detailed action mechanism of volatile general anesthetics is still unknown despite their effect has been clinically exploited for more than a century. Long ago it was also assessed that the potency of an anesthetic molecule well correlates with its lipophilicity and phospholipids were eventually identified as mediators. As yet, the direct effect of volatile anesthetics at physiological relevant concentrations on membranes is still under scrutiny. Organic field-effect transistors (OFETs) integrating a phospholipid (PL) functional bio inter-layer (FBI) are here proposed for the electronic detection of archetypal volatile anesthetic molecules such as diethyl ether and halothane. This technology allows to directly interface a PL layer to an electronic transistor channel, and directly probe subtle changes occurring in the bio-layer. Repeatable responses of PL FBI-OFET to anesthetics are produced in a concentration range that reaches few percent, namely the clinically relevant regime. The PL FBI-OFET is also shown to deliver a comparably weaker response to a non-anesthetic volatile molecule such as acetone"
Keywords:		"Anesthetics, General/*analysis Biosensing Techniques/*instrumentation Conductometry/*instrumentation Equipment Design Equipment Failure Analysis *Membranes, Artificial Organic Chemicals/chemistry Phospholipids/*chemistry Reproducibility of Results Sensiti;"
Notes:		"MedlineDaniela Angione, Maria Magliulo, Maria Cotrone, Serafina Mallardi, Antonia Altamura, Davide Giannini, Cinzia Cioffi, Nicola Sabbatini, Luigia Gobeljic, Danka Scamarcio, Gaetano Palazzo, Gerardo Torsi, Luisa eng Research Support, Non-U.S. Gov't England 2012/08/28 Biosens Bioelectron. 2013 Feb 15; 40(1):303-7. doi: 10.1016/j.bios.2012.07.068. Epub 2012 Aug 10"