| Title: | "Selected phenolic compounds in cultivated plants: ecologic functions, health implications, and modulation by pesticides" |
| Author(s): | Daniel O; Meier MS; Schlatter J; Frischknecht P; |
| Address: | "Section of Toxicology, Swiss Federal Office of Public Health, Zurich. otto.daniel@bag.admin.ch" |
| ISSN/ISBN: | 0091-6765 (Print) 0091-6765 (Linking) |
| Abstract: | "Phenolic compounds are widely distributed in the plant kingdom. Plant tissues may contain up to several grams per kilogram. External stimuli such as microbial infections, ultraviolet radiation, and chemical stressors induce their synthesis. The phenolic compounds resveratrol, flavonoids, and furanocoumarins have many ecologic functions and affect human health. Ecologic functions include defense against microbial pathogens and herbivorous animals. Phenolic compounds may have both beneficial and toxic effects on human health. Effects on low-density lipoproteins and aggregation of platelets are beneficial because they reduce the risk of coronary heart disease. Mutagenic, cancerogenic, and phototoxic effects are risk factors of human health. The synthesis of phenolic compounds in plants can be modulated by the application of herbicides and, to a lesser extent, insecticides and fungicides. The effects on ecosystem functioning and human health are complex and cannot be predicted with great certainty. The consequences of the combined natural and pesticide-induced modulating effects for ecologic functions and human health should be further evaluated" |
| Keywords: | Animals Coronary Disease/prevention & control Coumarins/*analysis/pharmacology Ecology Flavonoids/*analysis/pharmacology Herbicides/*toxicity Humans Phenols/*analysis/pharmacology Plants/*chemistry Resveratrol Stilbenes/*analysis/pharmacology; |
| Notes: | "MedlineDaniel, O Meier, M S Schlatter, J Frischknecht, P eng Review 1999/05/07 Environ Health Perspect. 1999 Feb; 107 Suppl 1(Suppl 1):109-14. doi: 10.1289/ehp.99107s1109" |
