| Title: | "Properties of Enterococcus faecalis plasmid pAD1, a member of a widely disseminated family of pheromone-responding, conjugative, virulence elements encoding cytolysin" |
| Address: | "Department of Biologic and Materials Sciences, School of Dentistry, The University of Michigan, Ann Arbor, MI 48109-1078, USA. dclewell@umich.edu" |
| DOI: | 10.1016/j.plasmid.2007.05.001 |
| ISSN/ISBN: | 0147-619X (Print) 0147-619X (Linking) |
| Abstract: | "The 60-kb pAD1 represents a large and widely disseminated family of conjugative, pheromone-responding, virulence plasmids commonly found in clinical isolates of Enterococcus faecalis. It encodes a hemolysin/bacteriocin (cytolysin) shown to contribute to virulence in animal models, and the related bacteriocin is active against a wide variety of Gram-positive bacteria. This review summarizes what is currently known about the molecular biology of pAD1, including aspects of its cytolytic, UV-resistance, replication, maintenance, and conjugative properties" |
| Keywords: | "Bacterial Proteins/genetics/physiology Conjugation, Genetic Enterococcus faecalis/*genetics/pathogenicity/physiology Oligopeptides/*physiology Perforin/*genetics *Plasmids Ultraviolet Rays Virulence;" |
| Notes: | "MedlineClewell, Don B eng AI10318/AI/NIAID NIH HHS/ GM33956/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Review 2007/06/26 Plasmid. 2007 Nov; 58(3):205-27. doi: 10.1016/j.plasmid.2007.05.001. Epub 2007 Jun 27" |
