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Pediatr Infect Dis J

Title:		"Preclinical Detection of Non-catheter Related Late-onset Sepsis in Preterm Infants by Fecal Volatile Compounds Analysis: A Prospective, Multi-center Cohort Study"
Author(s):		Berkhout DJC; Niemarkt HJ; Andriessen P; Vijlbrief DC; Bomers MK; Cossey V; Hulzebos CV; van Kaam AH; Kramer BW; van Lingen RA; Wicaksono AN; Covington JA; van Weissenbruch MM; Benninga MA; de Boer NKH; de Meij TGJ;
Address:		"From the Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. Neonatal Intensive Care Unit, Maxima Medical Centre, Veldhoven, the Netherlands. Department of Pediatrics, Maastricht University Medical Centre, Maastricht, the Netherlands. Neonatal Intensive Care Unit, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, the Netherlands. Internal medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium. Neonatal Intensive Care Unit, Beatrix Children's Hospital/ University Medical Centre Groningen, Groningen, the Netherlands. Neonatal Intensive Care Unit, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. Neonatal Intensive Care Unit, Amalia Children's Centre/ Isala, Zwolle, the Netherlands. School of Engineering, University of Warwick, Warwick, United Kingdom. Neonatal Intensive Care Unit, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Department of Gastroenterology and Hepatology , Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands"
Journal Title:		Pediatr Infect Dis J
Year:		2020
Volume:		39
Issue:		4
Page Number:		330 - 335
DOI:		10.1097/INF.0000000000002589
ISSN/ISBN:		1532-0987 (Electronic) 0891-3668 (Linking)
Abstract:		"BACKGROUND: Late onset sepsis (LOS) in preterm infants is preceded by fecal volatile organic compound (VOC) alterations, suggesting an etiologic role of gut microbiota in LOS rather than being primarily caused by central venous catheters (CVC). To increase our knowledge about the involvement of the gut microbiota in LOS, we analyzed fecal samples from septic infants without a CVC. METHODS: In this prospective multicenter study, fecal samples were collected daily from all infants born at
Keywords:		"Central Venous Catheters Feces/*chemistry Gastrointestinal Microbiome/physiology Gestational Age Humans Infant, Newborn Infant, Premature Intensive Care Units, Neonatal/statistics & numerical data Late Onset Disorders/*diagnosis/etiology Neonatal Sepsis/*;"
Notes:		"MedlineBerkhout, Daniel J C Niemarkt, Hendrik J Andriessen, Peter Vijlbrief, Daniel C Bomers, Marije K Cossey, Veerle Hulzebos, Christian V van Kaam, Anton H Kramer, Boris W van Lingen, Richard A Wicaksono, Alfian N Covington, James A van Weissenbruch, Mirjam M Benninga, Marc A de Boer, Nanne K H de Meij, Tim G J eng Multicenter Study Research Support, Non-U.S. Gov't 2020/02/08 Pediatr Infect Dis J. 2020 Apr; 39(4):330-335. doi: 10.1097/INF.0000000000002589"